腰椎间盘突出炎性因子与神经根性疼痛相关性研究(1)
摘 要：目的 研究腰椎間盘突出后炎性因子与神经根性疼痛的相关性。方法 收集2016年10月～2017年10月住院治疗的符合纳入标准的腰椎间盘突出症患者20例作为观察组，依据MRI检查结果将观察组分为膨出型6例(观察组A)、突出型9例(观察组B)和游离型5例(观察组C)；收集正常人20例作为对照组。入院后采集静脉血，采用Elisa检测炎性因子IL-1、IL-6、IL-18和TNF-α表达水平，采用VAS评分评价各组神经根性疼痛程度，采用相关性分析研究IL-1、IL-6、IL-18和TNF-α表达水平和VAS评分之间的相关性。结果 与对照组比较，A组、B组和C组的炎性因子表达水平和VAS评分增高，差异具有统计学意义(P<0.05)；与A组比较，B组和C组的炎性因子表达水平和VAS评分增高，差异具有统计学意义(P<0.05)；与B组比较，C组的炎性因子表达水平和VAS评分增高，差异具有统计学意义(P<0.05)。腰椎间盘突出后炎性因子IL-1、IL-6、IL-18和TNF-α表达水平与神经根性疼痛呈正相关。结论 腰椎间盘突出症患者静脉血中炎性因子IL-1、IL-6、IL-18和TNF-α表达水平较正常人高，且随着腰椎间盘突出程度的加重而升高，与神经根性疼痛之间存在正相关关系，可作为一项指标反映神经根性疼痛程度，将神经根性疼痛量化和数据化，有利于指导临床用药剂量和治疗，更好地评判疗效。
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关键词：腰椎间盘突出症；神经根性疼痛；炎性因子
中图分类号：R681.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.15.019
文章编号：1006-1959(2018)15-0059-05
Correlation between Inflammatory Factors and Nerve Root Pain in Protrusion of Lumbar Intervertebral Disc
WANG Qin-fen，ZHOU Shi-guo，LIU Guo-ming，LIN Shi-shui
(Department of Orthopaedics，Jinshan Hospital，Fuzhou 350001，Fujian，China)
, http://www.100md.com
Abstract：Objective To study the relationship between inflammatory factors after protrusion of lumbar intervertebral disc and nerve root pain.Methods From October 2016 to October 2017，20 patients with protrusion of lumbar intervertebral disc who were admitted to hospital selected as observation group.According to the results of MRI，the observation group was divided into 6 cases of exophthalmic type(observation group A)，9 cases of protrusion type(observation group B)and 5 cases of free type(observation group C)； 20 normal person were collected as the control group.After admission，venous blood was collected，and the expression of IL-1，IL-6，IL-18 and TNF- α expression was detected by Elisa.The degree of nerve root pain was evaluated by VAS score.The correlation between IL-1，IL-6，IL-18 and TNF-α expression and VAS score was studied by correlation analysis.Results Compared with the control group， the levels of inflammatory factors and VAS scores in group A，group B and group C were significantly higher，the difference was statistically significant(P<0.05).Compared with group A，the expression level of inflammatory factors and VAS scores in group B and C were higher，and the difference was statistically significant(P<0.05).Compared with group B，the expression level of inflammatory factors and VAS score in group C were higher，and the difference was statistically significant(P<0.05).The expression levels of inflammatory factors IL-1，IL-6，IL-18 and TNF-α were positively correlated with nerve root pain after protrusion of lumbar intervertebral disc.Conclusion The expression levels of inflammatory factors IL-1，IL-6，IL-18 and TNF-α in venous blood of patients with protrusion of lumbar intervertebral disc are higher than those of normal people.And increased with the degree of protrusion of lumbar intervertebral disc.There is a positive correlation with nerve root pain，which can be used as an indicator to reflect the degree of nerve root pain，to quantify and data radicular pain， to guide the dosage and treatment of clinical medication and to better evaluate the curative effect., http://www.100md.com(王钦奋 周仕国 刘国铭 林世水)
, http://www.100md.com
关键词：腰椎间盘突出症；神经根性疼痛；炎性因子
中图分类号：R681.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.15.019
文章编号：1006-1959(2018)15-0059-05
Correlation between Inflammatory Factors and Nerve Root Pain in Protrusion of Lumbar Intervertebral Disc
WANG Qin-fen，ZHOU Shi-guo，LIU Guo-ming，LIN Shi-shui
(Department of Orthopaedics，Jinshan Hospital，Fuzhou 350001，Fujian，China)
, http://www.100md.com
Abstract：Objective To study the relationship between inflammatory factors after protrusion of lumbar intervertebral disc and nerve root pain.Methods From October 2016 to October 2017，20 patients with protrusion of lumbar intervertebral disc who were admitted to hospital selected as observation group.According to the results of MRI，the observation group was divided into 6 cases of exophthalmic type(observation group A)，9 cases of protrusion type(observation group B)and 5 cases of free type(observation group C)； 20 normal person were collected as the control group.After admission，venous blood was collected，and the expression of IL-1，IL-6，IL-18 and TNF- α expression was detected by Elisa.The degree of nerve root pain was evaluated by VAS score.The correlation between IL-1，IL-6，IL-18 and TNF-α expression and VAS score was studied by correlation analysis.Results Compared with the control group， the levels of inflammatory factors and VAS scores in group A，group B and group C were significantly higher，the difference was statistically significant(P<0.05).Compared with group A，the expression level of inflammatory factors and VAS scores in group B and C were higher，and the difference was statistically significant(P<0.05).Compared with group B，the expression level of inflammatory factors and VAS score in group C were higher，and the difference was statistically significant(P<0.05).The expression levels of inflammatory factors IL-1，IL-6，IL-18 and TNF-α were positively correlated with nerve root pain after protrusion of lumbar intervertebral disc.Conclusion The expression levels of inflammatory factors IL-1，IL-6，IL-18 and TNF-α in venous blood of patients with protrusion of lumbar intervertebral disc are higher than those of normal people.And increased with the degree of protrusion of lumbar intervertebral disc.There is a positive correlation with nerve root pain，which can be used as an indicator to reflect the degree of nerve root pain，to quantify and data radicular pain， to guide the dosage and treatment of clinical medication and to better evaluate the curative effect., http://www.100md.com(王钦奋 周仕国 刘国铭 林世水)