MMP—2在ST段抬高性心肌梗死中的预后评估价值分析(1)
摘 要：目的 通过研究血浆MMP-2在ST段抬高性心肌梗死患者的表达，进一步分析MMP-2对近期的主要不良心血管事件的评估价值。方法 选取我院2013年9月～2015年9月ST段抬高性心肌梗死患者110例作为实验组，选取同期身体健康的体检志愿者50例作为对照组。用酶联免疫吸附试验检测两组患者血浆MMP-2浓度，比较两组男性比例、年龄、BMI、空腹血糖、总胆固醇、血肌酐以及MMP-2水平；通过GFRACE评分核定实验组入院GRACE积分，观察住院期间的MACE发生情况。结果 实验组的男性比例、年龄、空腹血糖、血肌酐以及MMP-2水平均高于对照组，差异具有统计学意义(P<0.05)；两组BMI和总胆固醇水平相比，差异无统计学意义(P>0.05)。实验组患者住院期间累计发生MACE共16例(14.55%)；基线入院GRACE评分、血浆MMP-2水平预测STEMI患者发生MACE的AUC分别为0.747(SE=0.069，P=0.006，95%CI 0.597～0.863)、0.721(SE=0.077，P=0.016，95%CI 0.567～0.846)。结论 MMP-2参与了急性心肌梗死的发生过程，对STEMI患者在院期间MACE事件的发生有一定的评估价值。
, 百拇医药
关键词：ST段抬高性心肌梗死；基质金属蛋白酶-2；危险性评估
中图分类号：R542.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.021
文章编号：1006-1959(2018)17-0071-04
Abstract：Objective To investigate the value of MMP-2 in the evaluation of recent major adverse cardiovascular events by studying the expression of plasma MMP-2 in patients with ST-segment elevation myocardial infarction.Methods A total of 110 patients with ST-segment elevation myocardial infarction from September 2013 to September 2015 were selected as the experimental group.50 healthy volunteers were selected as the control group.The levels of plasma MMP-2 in the two groups were measured by enzyme-linked immunosorbent assay (ELISA).The proportion，age，BMI，fasting blood glucose，total cholesterol，serum creatinine and MMP-2 levels of the two groups were compared.The GRACE scores of the experimental group were confirmed by GFRACE score.Observe the occurrence of MACE during hospitalization.Results The male proportion，age，fasting blood glucose，serum creatinine and MMP-2 levels in the experimental group were higher than those in the control group，the difference was statistically significant(P<0.05).There was no significant difference between the two groups in BMI and total cholesterol levels(P>0.05).A total of 16 patients(14.55%)had a cumulative MACE during the hospitalization period.Baseline admission GRACE score and plasma MMP-2 level predicted AUC of MACE in STEMI patients were 0.747(SE=0.069，P=0.006，95%CI 0.597～0.863)，0.721(SE=0.077，P=0.016，95% CI 0.567～0.846). Conclusion MMP-2 is involved in the pathogenesis of acute myocardial infarction，and it has certain evaluation value for the occurrence of MACE events in patients with STEMI.
, 百拇医药
Key words：ST-segment elevation myocardial infarction；Matrix metalloproteinase-2；Risk assessment
心血管疾病的危險因素除了常见的高血压、糖尿病、血脂异常之外，慢性炎症也扮演了重要角色，炎症反应致使动脉粥样硬化的表达上调。基质金属蛋白酶-2(matrix metalloproteinase-2，MMP-2)促进粥样斑块的纤维基质逐步降解，导致其稳定性明显下降，最终导致斑块破裂，进而触发血栓，在ST段抬高性心肌梗死(ST-segment elevation myocardial infarction，STEMI)的过程中起到重要作用[1-3]。纳入了多种临床因素的急性冠脉事件全球注册风险评分系统(global registry of acute coronary events，GRACE)是目前临床医生评估STEMI患者预后的主要评估工具[4]，本研究通过检测MMP-2在我院110例STEMI患者外周血中的表达水平，观察MMP-2的时间依耐性变化趋势，探讨MMP-2对STEMI预后的评估价值。, http://www.100md.com(郭俊林 张立)
, 百拇医药
关键词：ST段抬高性心肌梗死；基质金属蛋白酶-2；危险性评估
中图分类号：R542.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.021
文章编号：1006-1959(2018)17-0071-04
Abstract：Objective To investigate the value of MMP-2 in the evaluation of recent major adverse cardiovascular events by studying the expression of plasma MMP-2 in patients with ST-segment elevation myocardial infarction.Methods A total of 110 patients with ST-segment elevation myocardial infarction from September 2013 to September 2015 were selected as the experimental group.50 healthy volunteers were selected as the control group.The levels of plasma MMP-2 in the two groups were measured by enzyme-linked immunosorbent assay (ELISA).The proportion，age，BMI，fasting blood glucose，total cholesterol，serum creatinine and MMP-2 levels of the two groups were compared.The GRACE scores of the experimental group were confirmed by GFRACE score.Observe the occurrence of MACE during hospitalization.Results The male proportion，age，fasting blood glucose，serum creatinine and MMP-2 levels in the experimental group were higher than those in the control group，the difference was statistically significant(P<0.05).There was no significant difference between the two groups in BMI and total cholesterol levels(P>0.05).A total of 16 patients(14.55%)had a cumulative MACE during the hospitalization period.Baseline admission GRACE score and plasma MMP-2 level predicted AUC of MACE in STEMI patients were 0.747(SE=0.069，P=0.006，95%CI 0.597～0.863)，0.721(SE=0.077，P=0.016，95% CI 0.567～0.846). Conclusion MMP-2 is involved in the pathogenesis of acute myocardial infarction，and it has certain evaluation value for the occurrence of MACE events in patients with STEMI.
, 百拇医药
Key words：ST-segment elevation myocardial infarction；Matrix metalloproteinase-2；Risk assessment
心血管疾病的危險因素除了常见的高血压、糖尿病、血脂异常之外，慢性炎症也扮演了重要角色，炎症反应致使动脉粥样硬化的表达上调。基质金属蛋白酶-2(matrix metalloproteinase-2，MMP-2)促进粥样斑块的纤维基质逐步降解，导致其稳定性明显下降，最终导致斑块破裂，进而触发血栓，在ST段抬高性心肌梗死(ST-segment elevation myocardial infarction，STEMI)的过程中起到重要作用[1-3]。纳入了多种临床因素的急性冠脉事件全球注册风险评分系统(global registry of acute coronary events，GRACE)是目前临床医生评估STEMI患者预后的主要评估工具[4]，本研究通过检测MMP-2在我院110例STEMI患者外周血中的表达水平，观察MMP-2的时间依耐性变化趋势，探讨MMP-2对STEMI预后的评估价值。, http://www.100md.com(郭俊林 张立)