帕金森病嗅觉改变的相关性研究(1)
摘 要：目的 探讨帕金森病患者嗅觉功能改变及其与病程、病情和年龄的关系以及可能对帕金森病诊断的价值。方法 选取我院2014年3 月～2017年8月帕金森病住院患者41例为病例组，选择同期住院患者健康家属41例为对照组，应用简易嗅觉测定的方法分别对病例组和对照组进行嗅觉功能进行评估，比较两组的嗅觉功能，分析年龄，病程，Hoehn-Yahr(H-Y)分级与嗅觉的相关性。结果 病例组嗅觉障碍的发生率为85.36%，高于对照组26.82%，统计学意义显著(P<0.01)；在Hoehn-Yahr分级Ⅰ～Ⅱ级嗅觉障碍发生率高于Ⅳ级，差异有统计学意义(P<0.05)；其与年龄、病程无关(P>0.05)。结论 帕金森病患者存在嗅觉功能异常，其与病程、年龄无关，与病情相关。
关键词：帕金森病；嗅觉障碍；简易嗅觉检测
中图分类号：R742.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.029
, 百拇医药
文章编号：1006-1959(2018)17-0095-03
Abstract：Objective To investigate the changes of olfactory function in patients with Parkinson's disease and their relationship with disease course， condition and age，and the value of possible diagnosis of Parkinson's disease.Methods A total of 41 hospitalized patients with Parkinson's disease from March 2014 to August 2017 were selected as the case group.41 healthy family members of the same period were selected as the control group.The simple olfactory measurement method was used to control the case group and the control group.The olfactory function was evaluated，the olfactory function of the two groups was compared，and the age，duration of disease，Hoehn-Yahr(H-Y)grading and olfactory correlation were analyzed.Results The incidence of olfactory disturbance in the case group was 85.36%，which was higher than that in the control group 26.82%，the statistical significance was significant(P<0.01)；the incidence of olfactory disturbance in Hoehn-Yahr grade I～II was higher than that in grade IV，the difference was statistically significant(P<0.05)；it was not related to age and duration(P>0.05).Conclusion Patients with Parkinson's disease have abnormal olfactory function，which is not related to the course of disease and age，and is related to the condition.
, 百拇医药
Key words：Parkinson's disease；Olfactory disorder；Simple olfactory detection
帕金森病(parkinson's disease，PD)是一種中枢神经系统变性疾病，以静止性震颤、运动迟缓、肌强直、姿势步态障碍为主要临床特征。有研究发现，帕金森病除典型的运动症状外，还有一些如嗅觉减退，睡眠障碍等非运动症状，并早于运动症状出现，其中嗅觉障碍是最具代表性的非运动症状之一[1]。为进一步探讨PD患者的嗅觉功能改变及其与年龄、病程、病情的相关性及可能的诊断价值，我们采用简易的嗅觉检测方法，对41例原发性PD患者的嗅觉功能进行检测，并与健康成人作对照，来评估帕金森病患者的嗅觉功能，现总结如下。
1资料与方法
1.1研究对象 选取2014年3 月～2017年8月阎良区中医院内科门诊和少数内科住院的原发性PD患者41例作为病例组。纳入标准：①符合英国帕金森病协会脑库制定的帕金森病诊断标准；②患者及家属对检查知情同意并签署知情同意书。排除标准：①可能有影响嗅觉的其他神经疾病如老年性痴呆(入选病例MMSE 评分均>23 分)、癫痫、精神分裂症、先天发育不全、精神障碍等；②有鼻或鼻窦疾病，有头部外伤和酗酒史，近期(4周)有上呼吸道感染。③用影响多巴胺转运体结合或影响嗅觉功能的其他治疗；如单胺氧化酶抑制剂、雌激素、类固醇激素等；④检查不合作者。病例组男性23 例，女性18例，年龄44～80岁，平均年龄(61.12±9.13)岁，其中<60 岁21 例，≥60 岁20 例；病程(3个月～13年)，平均病程(4.19±2.75)年，其中1 年以内5例，1～5 年21 例，5 年以上15例；采用Hoehn-Yahr分期将病例组患者病情分为轻度(Ⅰ～Ⅱ级)16例，中度(Ⅲ级)10例，重度(Ⅳ级)15例。另选择同期住院患者的健康家属41例，男性23 例，女性18例，年龄44～80岁，平均年龄(61.12±9.13)岁。两组患者性别、年龄一般资料对比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(樊毅)
关键词：帕金森病；嗅觉障碍；简易嗅觉检测
中图分类号：R742.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.029
, 百拇医药
文章编号：1006-1959(2018)17-0095-03
Abstract：Objective To investigate the changes of olfactory function in patients with Parkinson's disease and their relationship with disease course， condition and age，and the value of possible diagnosis of Parkinson's disease.Methods A total of 41 hospitalized patients with Parkinson's disease from March 2014 to August 2017 were selected as the case group.41 healthy family members of the same period were selected as the control group.The simple olfactory measurement method was used to control the case group and the control group.The olfactory function was evaluated，the olfactory function of the two groups was compared，and the age，duration of disease，Hoehn-Yahr(H-Y)grading and olfactory correlation were analyzed.Results The incidence of olfactory disturbance in the case group was 85.36%，which was higher than that in the control group 26.82%，the statistical significance was significant(P<0.01)；the incidence of olfactory disturbance in Hoehn-Yahr grade I～II was higher than that in grade IV，the difference was statistically significant(P<0.05)；it was not related to age and duration(P>0.05).Conclusion Patients with Parkinson's disease have abnormal olfactory function，which is not related to the course of disease and age，and is related to the condition.
, 百拇医药
Key words：Parkinson's disease；Olfactory disorder；Simple olfactory detection
帕金森病(parkinson's disease，PD)是一種中枢神经系统变性疾病，以静止性震颤、运动迟缓、肌强直、姿势步态障碍为主要临床特征。有研究发现，帕金森病除典型的运动症状外，还有一些如嗅觉减退，睡眠障碍等非运动症状，并早于运动症状出现，其中嗅觉障碍是最具代表性的非运动症状之一[1]。为进一步探讨PD患者的嗅觉功能改变及其与年龄、病程、病情的相关性及可能的诊断价值，我们采用简易的嗅觉检测方法，对41例原发性PD患者的嗅觉功能进行检测，并与健康成人作对照，来评估帕金森病患者的嗅觉功能，现总结如下。
1资料与方法
1.1研究对象 选取2014年3 月～2017年8月阎良区中医院内科门诊和少数内科住院的原发性PD患者41例作为病例组。纳入标准：①符合英国帕金森病协会脑库制定的帕金森病诊断标准；②患者及家属对检查知情同意并签署知情同意书。排除标准：①可能有影响嗅觉的其他神经疾病如老年性痴呆(入选病例MMSE 评分均>23 分)、癫痫、精神分裂症、先天发育不全、精神障碍等；②有鼻或鼻窦疾病，有头部外伤和酗酒史，近期(4周)有上呼吸道感染。③用影响多巴胺转运体结合或影响嗅觉功能的其他治疗；如单胺氧化酶抑制剂、雌激素、类固醇激素等；④检查不合作者。病例组男性23 例，女性18例，年龄44～80岁，平均年龄(61.12±9.13)岁，其中<60 岁21 例，≥60 岁20 例；病程(3个月～13年)，平均病程(4.19±2.75)年，其中1 年以内5例，1～5 年21 例，5 年以上15例；采用Hoehn-Yahr分期将病例组患者病情分为轻度(Ⅰ～Ⅱ级)16例，中度(Ⅲ级)10例，重度(Ⅳ级)15例。另选择同期住院患者的健康家属41例，男性23 例，女性18例，年龄44～80岁，平均年龄(61.12±9.13)岁。两组患者性别、年龄一般资料对比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(樊毅)