慢性牙周炎伴肥胖患者血清中IL-6、IL-18表达水平的研究(1)
摘要：目的 探究白細胞介素6(IL-6)、白细胞介素18(IL-18)在肥胖慢性牙周炎患者血清中的表达水平变化及意义。方法 选取2017年9月～2018年5月在佳木斯大学附属口腔医院牙周科门诊确诊为慢性牙周炎患者15例设为NP组，另选取同期慢性牙周炎伴肥胖患者15例设为FP组。收集两组患者外周血样本并记录牙周PD、CAL，采用双抗体夹心酶联免疫吸附法(ELISA法)测定样本中的IL-6、IL-18的表达水平，分析两组间指标的差异及相关性。结果 FP组血清中IL-6、IL-18分别为(9.16±2.35)pg/ml、(325.22±98.67)pg/ml，其表达水平分别高于NP组的(6.15±2.06)pg/ml和(241.52±78.82)pg/ml，差异有统计学意义(P<0.05);FP组中PD与血清中IL-6、IL-18呈高度正相关(r=0.894，P<0.01;r=0.819，P<0.01);CAL与血清中IL-6、IL-18呈正相关(r=0.885，P<0.01，r=0.828，P<0.01);NP组中PD与血清中IL-6、IL-18也有正相关关系(r=0.842，P<0.01，r=0.728，P<0.01);CAL与血清中IL-6、IL-18呈正相关(r=0.884，P<0.01，r=0.707，P<0.01)。结论 肥胖状态所导致的外周血中IL-6、IL-18水平的升高与CP的发生发展存在着密切联系。
, 百拇医药
关键词：慢性牙周炎;肥胖;IL-6;IL-18
中图分类号：R781.4+2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.028
文章编号：1006-1959(2019)01-0092-04
Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with
Chronic Periodontitis and Obesity
CHU Fu-xing，LI Shan-shan，LI Si-qi，LI Wei-shan
, 百拇医药
(Periodontal Oral Mucosa of Stomatological Hospital Affiliated Jiamusi University，Jiamusi154004，Heilongjiang，China)
Abstract：Objective To investigate the changes and significance of interleukin-6 (IL-6) and interleukin-18 (IL-18) expression in serum of obese chronic periodontitis patients. Methods From September 2017 to May 2018， 15 patients with chronic periodontitis diagnosed in the periodontal clinic of Jiamusi University Hospital of Stomatology were selected as NP group， and 15 patients with chronic periodontitis and obesity were selected as FPgroup. Peripheral blood samples were collected from both groups and PD and CAL were recorded. The expression levels of IL-6 and IL-18 in the samples were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The differences and correlations between the two groups were analyzed. Results The serum levels of IL-6 and IL-18 in FP group were (9.16±2.35) pg/ml and (325.22±98.67) pg/ml， respectively， and their expression levels were higher than that of NP group (6.15±2.06) pg/ml and (241.52±78.82) pg/ml， the difference was statistically significant (P<0.05); PD in the FP group was highly positively correlated with serum IL-6 and IL-18 (r=0.894， P<0.01;r=0.819，P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.885， P<0.01， r=0.828， P<0.01);There was a positive correlation between PD and serum IL-6 and IL-18 in NP group (r=0.842，P<0.01，r=0.728， P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.884，P<0.01，r=0.707，P<0.01). Conclusion The increase of IL-6 and IL-18 levels in peripheral blood caused by obesity is closely related to the occurrence and development of CP., http://www.100md.com(褚福行 李珊珊 李思琪 李维善)
, 百拇医药
关键词：慢性牙周炎;肥胖;IL-6;IL-18
中图分类号：R781.4+2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.028
文章编号：1006-1959(2019)01-0092-04
Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with
Chronic Periodontitis and Obesity
CHU Fu-xing，LI Shan-shan，LI Si-qi，LI Wei-shan
, 百拇医药
(Periodontal Oral Mucosa of Stomatological Hospital Affiliated Jiamusi University，Jiamusi154004，Heilongjiang，China)
Abstract：Objective To investigate the changes and significance of interleukin-6 (IL-6) and interleukin-18 (IL-18) expression in serum of obese chronic periodontitis patients. Methods From September 2017 to May 2018， 15 patients with chronic periodontitis diagnosed in the periodontal clinic of Jiamusi University Hospital of Stomatology were selected as NP group， and 15 patients with chronic periodontitis and obesity were selected as FPgroup. Peripheral blood samples were collected from both groups and PD and CAL were recorded. The expression levels of IL-6 and IL-18 in the samples were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The differences and correlations between the two groups were analyzed. Results The serum levels of IL-6 and IL-18 in FP group were (9.16±2.35) pg/ml and (325.22±98.67) pg/ml， respectively， and their expression levels were higher than that of NP group (6.15±2.06) pg/ml and (241.52±78.82) pg/ml， the difference was statistically significant (P<0.05); PD in the FP group was highly positively correlated with serum IL-6 and IL-18 (r=0.894， P<0.01;r=0.819，P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.885， P<0.01， r=0.828， P<0.01);There was a positive correlation between PD and serum IL-6 and IL-18 in NP group (r=0.842，P<0.01，r=0.728， P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.884，P<0.01，r=0.707，P<0.01). Conclusion The increase of IL-6 and IL-18 levels in peripheral blood caused by obesity is closely related to the occurrence and development of CP., http://www.100md.com(褚福行 李珊珊 李思琪 李维善)