棕色脂肪形成的内分泌及环境影响因素研究(4)
[12]Holland WL，Adams AC，Brozinick JT，et al.An FGF21-adiponectin-ceramide axiscontrols energy expenditure and insulin action in mice[J].Cell Metab，2013，17(5)：790-797.
[13]Wang GX，Zhao XY，Lin JD.The brown fat secretome：metabolic functions beyond thermogenesis[J].Trends in Endocrinology and Metabolism，2015，26(5)：231-237.
[14]Barclay JL，Agada H，Jang C，et al.Effects of glucocorticoids on human brown adipocytes[J].Journal of Endocrinology，2015，224(2)：139-147.
, http://www.100md.com
[15]Sun L，Trajkovski M.MiR-27 orchestrates the transcriptional regulation of brown adipogenesis[J].Metabolism，2014，63(2)：272-282.
[16]Paakkonen T，Leppaluoto J.Cold exposure and hormonal secretion：a review[J].Int J Circumpolar Health，2002，61(2)：256-276.
[17]仝永娟，杨朵，李娜，等.低温低压环境对小鼠褐色脂肪组织形成的影响[J].中國比较医学杂志，2017，27(12)：61-65.
[18]Singh AK， Aryal B，Chaube B，et al.Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis[J].Mol Metab，2018(11)：59-69.
, 百拇医药
[19]Aryal B，Rotllan N，Araldi E，et al. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression[J]. Nat Commun，2016(7)：12313.
[20]Duta-Mare M ，Sachdev V，Leopold C，et al.Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis[J].Biochim Biophys Acta，2018，1863(4)：467-478.
[21]Berbee JF，Boon MR，Khedoe PP，et al.Borwn fat activation reduces hypercholesterolesterolaemia and protects from atherosclerosis development[J].Nat Commun，2015(6)：6356.
, 百拇医药
[22]Bartelt A，Bruns OT，Reimer R，et al.Brown adipose tissue activity controls triglyceride clearance[J].Nat Med，2013(19)：1252-1263.
[23]Yuan F，Lei Y，Wang Q，et al.Moderate ethanol administrationaccentuates cardiomyocyte contractile dysfunctionand mitochondrial injury in high fat diet-induced obesity[J].Toxicol Lett，2015，233(3)：267-277.
[24]Pino E，Wang H，McDonald ME，et al.Roles for peroxisome proliferator-activated receptor γ(PPARγ)and PPARγcoactivators 1α and 1β in regulating response of white and brown adipocytes to hypoxia[J].BiolChem，2012(287)：18351-18358.
, 百拇医药
[25]李佳，格日力.白色脂肪棕色化的调控因素及其潜在治疗[J].中国高原医学与生物学杂志，2017，38(6)：132-139
[26]Kajimura S，Saito M.A new era in brown adipose tissue biology： molecular controlof brown fat development and energy homeostasis[J].Annu Rev Physiol，2014(76)：225-249.
[27]Wang JM，Zhang YM，Wang DH.Seasonal thermogenesis and body mass regulation in plateau pikas(Ochotona curzoniae)[J].Oecologia，2006(149)：373-382.
[28]Bai Z，Wuren T，Liu S，et al.Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika.Comparatie Biochemistry and Physiology[J].2015(184)：171-178.
[29]白振忠.高原鼠兔对缺氧、寒冷极端高原环境适应的分子机制研究[D].青海大学，2015.
[30]Afshin A，Forouzanfar MH，Reitsma MB，et al.Health effects of overweight and obesity in 195 countries over 25 years[J].N Engl J Med，2017(377)：13-27，173-187.
收稿日期：2018-12-20;修回日期：2018-12-29
编辑/王朵梅, http://www.100md.com(庄俐 张惠莉 张瑞霞)
[13]Wang GX，Zhao XY，Lin JD.The brown fat secretome：metabolic functions beyond thermogenesis[J].Trends in Endocrinology and Metabolism，2015，26(5)：231-237.
[14]Barclay JL，Agada H，Jang C，et al.Effects of glucocorticoids on human brown adipocytes[J].Journal of Endocrinology，2015，224(2)：139-147.
, http://www.100md.com
[15]Sun L，Trajkovski M.MiR-27 orchestrates the transcriptional regulation of brown adipogenesis[J].Metabolism，2014，63(2)：272-282.
[16]Paakkonen T，Leppaluoto J.Cold exposure and hormonal secretion：a review[J].Int J Circumpolar Health，2002，61(2)：256-276.
[17]仝永娟，杨朵，李娜，等.低温低压环境对小鼠褐色脂肪组织形成的影响[J].中國比较医学杂志，2017，27(12)：61-65.
[18]Singh AK， Aryal B，Chaube B，et al.Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis[J].Mol Metab，2018(11)：59-69.
, 百拇医药
[19]Aryal B，Rotllan N，Araldi E，et al. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression[J]. Nat Commun，2016(7)：12313.
[20]Duta-Mare M ，Sachdev V，Leopold C，et al.Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis[J].Biochim Biophys Acta，2018，1863(4)：467-478.
[21]Berbee JF，Boon MR，Khedoe PP，et al.Borwn fat activation reduces hypercholesterolesterolaemia and protects from atherosclerosis development[J].Nat Commun，2015(6)：6356.
, 百拇医药
[22]Bartelt A，Bruns OT，Reimer R，et al.Brown adipose tissue activity controls triglyceride clearance[J].Nat Med，2013(19)：1252-1263.
[23]Yuan F，Lei Y，Wang Q，et al.Moderate ethanol administrationaccentuates cardiomyocyte contractile dysfunctionand mitochondrial injury in high fat diet-induced obesity[J].Toxicol Lett，2015，233(3)：267-277.
[24]Pino E，Wang H，McDonald ME，et al.Roles for peroxisome proliferator-activated receptor γ(PPARγ)and PPARγcoactivators 1α and 1β in regulating response of white and brown adipocytes to hypoxia[J].BiolChem，2012(287)：18351-18358.
, 百拇医药
[25]李佳，格日力.白色脂肪棕色化的调控因素及其潜在治疗[J].中国高原医学与生物学杂志，2017，38(6)：132-139
[26]Kajimura S，Saito M.A new era in brown adipose tissue biology： molecular controlof brown fat development and energy homeostasis[J].Annu Rev Physiol，2014(76)：225-249.
[27]Wang JM，Zhang YM，Wang DH.Seasonal thermogenesis and body mass regulation in plateau pikas(Ochotona curzoniae)[J].Oecologia，2006(149)：373-382.
[28]Bai Z，Wuren T，Liu S，et al.Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika.Comparatie Biochemistry and Physiology[J].2015(184)：171-178.
[29]白振忠.高原鼠兔对缺氧、寒冷极端高原环境适应的分子机制研究[D].青海大学，2015.
[30]Afshin A，Forouzanfar MH，Reitsma MB，et al.Health effects of overweight and obesity in 195 countries over 25 years[J].N Engl J Med，2017(377)：13-27，173-187.
收稿日期：2018-12-20;修回日期：2018-12-29
编辑/王朵梅, http://www.100md.com(庄俐 张惠莉 张瑞霞)