术前LMR和FIB的检测对结直肠中分化腺癌患者的临床意义(1)
摘要：目的 探討结直肠中分化腺癌患者术前淋巴细胞与单核细胞比值和纤维蛋白原在辅助诊断、术前评估中的价值。方法 收集2010年1月～2013年7月在安徽医科大学第三附属医院接受手术治疗的结直肠中分化腺癌患者100例设为观察组，另选同时期健康体检者50例设为对照组，比较两组LMR、FIB值。通过受试者工作曲线确定结直肠中分化腺癌患者LMR与FIB的最佳截断值，根据截断值分为高、低LMR组，高、低FIB组。分析LMR、FIB与结直肠癌患者临床特征的关系及与术后5年生存率的相关性。结果 观察组LMR值(3.39±1.48)低于对照组(5.27±0.98)，观察组FIB值(3.63±0.60)g/L高于对照组(2.78±0.41)g/L，统计学意义显著(P<0.01)。LMR、FIB的最佳截断值分别为3.65、3.495 g/L。高LMR组远处转移率为4.65%，低于低LMR组的21.05%，高LMR组在Ⅲ～Ⅳ期的比率为44.19%，低于低LMR组的64.91%，差异有统计学意义(P<0.05)。高FIB组远处转移率的22.22%，高于低FIB组的4.35%，高FIB组在Ⅲ～Ⅳ的比率为66.67%，高于低FIB组的43.48%，高FIB组淋巴结转移率为59.26%，高于低FIB组的34.78%，差异均有统计学意义(P<0.05)。高LMR组5年生存率为76.74%，高于低LMR组的47.37%，低FIB组5年生存率为78.26%，高于高FIB组的44.44%，统计学意义显著(P<0.01)。结论 术前LMR、FIB对结直肠中分化腺癌患者的辅助诊断、术前评估有一定临床价值。
, 百拇医药
关键词：结直肠中分化腺癌;淋巴细胞与单核细胞比值;纤维蛋白原;辅助诊断;术前评估
中图分类号：R753.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.031
文章编号：1006-1959(2019)04-0094-05
Abstract：Objective To investigate the value of preoperative lymphocyte and monocyte ratio and fibrinogen in the diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal. Methods 100 patients with colorectal differentiated adenocarcinoma who underwent surgery in the Third Affiliated Hospital of Anhui Medical University from January 2010 to July 2013 were enrolled in the observation group， and 50 healthy subjects in the same period were selected as the control group. The LMR and FIB values of the two groups were compared. The best cutoff values of LMR and FIB in patients with differentiated adenocarcinoma in colorectal were determined by receiver working curve. According to the cutoff value， they were divided into high and low LMR groups， high and low FIB groups. To analyze the relationship between LMR， FIB and clinical features of colorectal cancer patients and the correlation with 5-year survival rate. Results The LMR value of the observation group (3.39±1.48) was lower than that of the control group (5.27±0.98)， and the FIB value of the observation group (3.63±0.60) g/L was higher than that of the control group (2.78±0.41) g/L， which was statistically significant (P <0.01). The optimal cutoff values for LMR and FIB are 3.650 and 3.495 g/L， respectively. The distant metastasis rate of the high LMR group was 4.65%， Below 21.05% of the low LMR group， the ratio of the high LMR group was 44.19% in the III～IV phase， which was lower than the 64.91% in the low LMR group， the difference was statistically significant (P<0.05). The distant metastasis rate was 22.22% in the high FIB group，Compared with 4.35% in the low FIB group， the ratio of III to IV in the high FIB group was 66.67%， which was higher than 43.48% in the low FIB group， and the lymph node metastasis rate in the high FIB group was 59.26%， which was higher than that in the low FIB group 34.78%，the differences were statistically significant (P<0.05). The 5-year survival rate was 76.74% in the high LMR group， which was higher than the low LMR group 47.37%， and the 5-year survival rate was 78.26% in the low FIB group， which was higher than that in the high FIB group 44.44%，Statistically significant (P <0.01). Conclusion Preoperative LMR and FIB have certain clinical value in the auxiliary diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal cancer., 百拇医药(朱婷樱 鲍扬漪)
, 百拇医药
关键词：结直肠中分化腺癌;淋巴细胞与单核细胞比值;纤维蛋白原;辅助诊断;术前评估
中图分类号：R753.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.031
文章编号：1006-1959(2019)04-0094-05
Abstract：Objective To investigate the value of preoperative lymphocyte and monocyte ratio and fibrinogen in the diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal. Methods 100 patients with colorectal differentiated adenocarcinoma who underwent surgery in the Third Affiliated Hospital of Anhui Medical University from January 2010 to July 2013 were enrolled in the observation group， and 50 healthy subjects in the same period were selected as the control group. The LMR and FIB values of the two groups were compared. The best cutoff values of LMR and FIB in patients with differentiated adenocarcinoma in colorectal were determined by receiver working curve. According to the cutoff value， they were divided into high and low LMR groups， high and low FIB groups. To analyze the relationship between LMR， FIB and clinical features of colorectal cancer patients and the correlation with 5-year survival rate. Results The LMR value of the observation group (3.39±1.48) was lower than that of the control group (5.27±0.98)， and the FIB value of the observation group (3.63±0.60) g/L was higher than that of the control group (2.78±0.41) g/L， which was statistically significant (P <0.01). The optimal cutoff values for LMR and FIB are 3.650 and 3.495 g/L， respectively. The distant metastasis rate of the high LMR group was 4.65%， Below 21.05% of the low LMR group， the ratio of the high LMR group was 44.19% in the III～IV phase， which was lower than the 64.91% in the low LMR group， the difference was statistically significant (P<0.05). The distant metastasis rate was 22.22% in the high FIB group，Compared with 4.35% in the low FIB group， the ratio of III to IV in the high FIB group was 66.67%， which was higher than 43.48% in the low FIB group， and the lymph node metastasis rate in the high FIB group was 59.26%， which was higher than that in the low FIB group 34.78%，the differences were statistically significant (P<0.05). The 5-year survival rate was 76.74% in the high LMR group， which was higher than the low LMR group 47.37%， and the 5-year survival rate was 78.26% in the low FIB group， which was higher than that in the high FIB group 44.44%，Statistically significant (P <0.01). Conclusion Preoperative LMR and FIB have certain clinical value in the auxiliary diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal cancer., 百拇医药(朱婷樱 鲍扬漪)