高尿酸血症与中青年无症状性脑梗死的相关性分析(1)
摘要：目的 探討血清尿酸与中青年无症状性脑梗死的关系。方法 收集我院中青年患者300例，根据临床神经功能缺损症状及颅脑MRI或CT结果，分为无症状脑梗死组、有症状脑梗死组和对照组，每组100例。测定三组患者的血清尿酸、血脂、血糖水平。将高尿酸脑梗死患者分为口服苯溴马隆控制血尿酸组(控制组)和非控制尿酸组(非控制组)。控制组口服药物苯溴马隆片治疗，非控制组不接受药物治疗，两组每3个月进行随访。对高尿酸水平与中青年脑梗死进行Logistic多因素回归分析。结果 无症状脑梗死组、有症状脑梗死组和对照组高尿酸患者分别为41例、57例和18例，差异有统计学意义(P<0.05)。无症状性脑梗死组41例尿酸升高，进展为有症状脑梗死17例，59例尿酸正常，进展为有症状脑梗死7例，差异有统计学意义(P<0.05)。98例高尿酸脑梗死患者中，控制组50例进展为有症状性脑梗死或复发有7例，非控制组48例进展为有症状性脑梗死或复发有17例，差异有统计学意义(P<0.05)。高尿酸水平与中青年脑梗死的发生及进展有相关性(OR=1.31，95%CI=1.003～1.918，P<0.01)。结论 高尿酸水平与中青年脑梗死呈正相关，控制高尿酸可有效预防和降低中青年无症状脑梗死进展为急性脑梗死。
, 百拇医药
关键词：中青年;无症状性脑梗死;高尿酸血症;苯溴马隆
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.034
文章编号：1006-1959(2019)04-0107-03
Abstract：Objective To investigate the relationship between serum uric acid and asymptomatic cerebral infarction in young and middle-aged. Methods A total of 300 young and middle-aged patients in our hospital were enrolled. According to the clinical neurological deficit symptoms and brain MRI or CT results， they were divided into asymptomatic cerebral infarction group， symptomatic cerebral infarction group and control group， with 100 cases in each group. Serum uric acid， blood lipids， and blood glucose levels were measured in three groups of patients. Patients with hyperuricemia and cerebral infarction were divided into oral benzbromarone-controlled blood uric acid group (control group) and non-controlled uric acid group (non-control group). The control group received oral drug benzobromone tablets， the non-control group did not receive drug treatment， and the two groups were followed up every 3 months. Logistic multivariate regression analysis was performed on high uric acid level and middle-aged and young cerebral infarction. Results The asymptomatic cerebral infarction group， the symptomatic cerebral infarction group and the control group had 41 cases， 57 cases and 18 cases of high uric acid， respectively，the difference was statistically significant (P<0.05). In the asymptomatic cerebral infarction group， 41 patients had elevated uric acid， and 17 patients had symptomatic cerebral infarction. 59 patients had normal uric acid and 7 patients had symptomatic cerebral infarction，the difference was statistically significant (P<0.05).In 98 patients with hyperuricemia cerebral infarction， there were 7 cases of symptomatic cerebral infarction or recurrence in control group (50 cases) and 17 cases of symptomatic cerebral infarction or recurrence in non-control group (48 cases)，the difference was statistically significant (P<0.05). The level of high uric acid was correlated with the occurrence and progression of cerebral infarction in young and middle-aged patients (OR=1.31， 95%CI=1.003～1.918， P<0.01). Conclusion The level of high uric acid is positively correlated with cerebral infarction in young and middle-aged patients. Controlling high uric acid can effectively prevent and reduce the progression of asymptomatic cerebral infarction in young and middle-aged patients., 百拇医药(朱树花)
, 百拇医药
关键词：中青年;无症状性脑梗死;高尿酸血症;苯溴马隆
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.034
文章编号：1006-1959(2019)04-0107-03
Abstract：Objective To investigate the relationship between serum uric acid and asymptomatic cerebral infarction in young and middle-aged. Methods A total of 300 young and middle-aged patients in our hospital were enrolled. According to the clinical neurological deficit symptoms and brain MRI or CT results， they were divided into asymptomatic cerebral infarction group， symptomatic cerebral infarction group and control group， with 100 cases in each group. Serum uric acid， blood lipids， and blood glucose levels were measured in three groups of patients. Patients with hyperuricemia and cerebral infarction were divided into oral benzbromarone-controlled blood uric acid group (control group) and non-controlled uric acid group (non-control group). The control group received oral drug benzobromone tablets， the non-control group did not receive drug treatment， and the two groups were followed up every 3 months. Logistic multivariate regression analysis was performed on high uric acid level and middle-aged and young cerebral infarction. Results The asymptomatic cerebral infarction group， the symptomatic cerebral infarction group and the control group had 41 cases， 57 cases and 18 cases of high uric acid， respectively，the difference was statistically significant (P<0.05). In the asymptomatic cerebral infarction group， 41 patients had elevated uric acid， and 17 patients had symptomatic cerebral infarction. 59 patients had normal uric acid and 7 patients had symptomatic cerebral infarction，the difference was statistically significant (P<0.05).In 98 patients with hyperuricemia cerebral infarction， there were 7 cases of symptomatic cerebral infarction or recurrence in control group (50 cases) and 17 cases of symptomatic cerebral infarction or recurrence in non-control group (48 cases)，the difference was statistically significant (P<0.05). The level of high uric acid was correlated with the occurrence and progression of cerebral infarction in young and middle-aged patients (OR=1.31， 95%CI=1.003～1.918， P<0.01). Conclusion The level of high uric acid is positively correlated with cerebral infarction in young and middle-aged patients. Controlling high uric acid can effectively prevent and reduce the progression of asymptomatic cerebral infarction in young and middle-aged patients., 百拇医药(朱树花)