舍曲林联合拉莫三嗪治疗精神分裂症后抑郁的疗效观察(1)
摘要：目的 探讨拉莫三嗪治疗精神分裂症后抑郁的临床疗效、抑郁评分的变化及安全性。方法 选取2017年8月～2018年11月在我院住院的精神分裂症患者80例，随机分为对照组和观察组，每组40例。对照组给予抗精神病药物治疗的同时联用舍曲林治疗，观察组在对照组的基础上加用拉莫三嗪治疗，疗程8周。采用汉密尔顿抑郁量表(HAMD17)、临床疗效总评量表(CGI)、治疗中出现的副反应量表(TESS)分别在治疗前、治疗后第1、2、4、8周对两组的疗效、不良反应发生率进行统计分析。结果 两组治疗1、2、4、8周后的HAMD、CGI评分均低于治疗前，且观察组低于对照组，差异有统计学意义(P<0.05)。治疗8周后，观察组痊愈率为95.00%(38/40)，高于对照组的80.00%(32/40)，差异有统计学意义(P<0.05)。两组患者治疗1、2、4、8周时的TESS评分比较，差异无统计学意义(P>0.05)。观察组不良反应发生率为27.50%(11/40)，对照组为20.00%(8/40)，两组比较，差异无统计学意义(P>0.05)。结论 拉莫三嗪与舍曲林联合治疗比单用舍曲林治疗精神分裂症后抑郁疗效更好，起效更快，未增加不良反应，有较好的应用价值。
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关键词：拉莫三嗪;舍曲林;精神分裂症;抑郁
中图分类号：R749.3 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.052
文章编号：1006-1959(2019)06-0161-03
Abstract：Objective To investigate the clinical efficacy， depression score and safety of lamotrigine in the treatment of post-schizophrenia depression. Methods 80 patients with schizophrenia admitted to our hospital from August 2017 to November 2018 were randomly divided into the control group and the observation group， with 40 cases in each group. The control group was treated with antipsychotic drugs and treated with sertraline. The observation group was treated with lamotrigine on the basis of the control group for 8 weeks. The Hamilton Depression Scale (HAMD17)， the Clinical Outcome Scale (CGI)， and the Side Effects Scale (TESS) during treatment were used to treat the two groups before treatment and at 1， 2， 4， and 8 weeks after treatment. Statistical analysis of the incidence of adverse reactions. Results The HAMD and CGI scores of the two groups after treatment for 1， 2， 4 and 8 weeks were lower than those before treatment， and the observation group was lower than the control group， the difference was statistically significant (P<0.05). After 8 weeks of treatment， the cure rate of the observation group was 95.00% (38/40)， which was higher than that of the control group 80.00% (32/40). The difference was statistically significant (P<0.05).There was no significant difference in the TESS scores between the two groups at 1， 2， 4， and 8 weeks (P>0.05). The incidence of adverse reactions was 27.50% (11/40) in the observation group and 20.00% (8/40) in the control group. There was no significant difference between the two groups (P>0.05). Conclusion The combination of lamotrigine and sertraline is more effective than sertraline alone in the treatment of post-schizophrenia depression. It has a faster onset， no increase in adverse reactions， and has good application value., 百拇医药(聂永新 占海港 杨盆英)
, http://www.100md.com
关键词：拉莫三嗪;舍曲林;精神分裂症;抑郁
中图分类号：R749.3 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.052
文章编号：1006-1959(2019)06-0161-03
Abstract：Objective To investigate the clinical efficacy， depression score and safety of lamotrigine in the treatment of post-schizophrenia depression. Methods 80 patients with schizophrenia admitted to our hospital from August 2017 to November 2018 were randomly divided into the control group and the observation group， with 40 cases in each group. The control group was treated with antipsychotic drugs and treated with sertraline. The observation group was treated with lamotrigine on the basis of the control group for 8 weeks. The Hamilton Depression Scale (HAMD17)， the Clinical Outcome Scale (CGI)， and the Side Effects Scale (TESS) during treatment were used to treat the two groups before treatment and at 1， 2， 4， and 8 weeks after treatment. Statistical analysis of the incidence of adverse reactions. Results The HAMD and CGI scores of the two groups after treatment for 1， 2， 4 and 8 weeks were lower than those before treatment， and the observation group was lower than the control group， the difference was statistically significant (P<0.05). After 8 weeks of treatment， the cure rate of the observation group was 95.00% (38/40)， which was higher than that of the control group 80.00% (32/40). The difference was statistically significant (P<0.05).There was no significant difference in the TESS scores between the two groups at 1， 2， 4， and 8 weeks (P>0.05). The incidence of adverse reactions was 27.50% (11/40) in the observation group and 20.00% (8/40) in the control group. There was no significant difference between the two groups (P>0.05). Conclusion The combination of lamotrigine and sertraline is more effective than sertraline alone in the treatment of post-schizophrenia depression. It has a faster onset， no increase in adverse reactions， and has good application value., 百拇医药(聂永新 占海港 杨盆英)