抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义(1)
摘要：目的 探究抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义。方法 选取2017年11月～2018年11月我院收治的30例类风湿关节炎患者设为研究组，另选取同期进行健康体检者30例设为对照组，对两组进行抗CCP抗体与RF联合检测，并且分析抗CCP抗體、RF单独及两者联合检测的敏感性、特异性、阳性预测值和阴性预测值。结果 研究组抗CCP抗体阳性率96.67%、RF阳性率93.33%和两者联合检测阳性率86.67%均高于对照组的6.67%、3.33%及3.33%;研究组抗CCP抗体水平(78.65±14.33)U/ml和RF水平(314.22±20.56)IU/ml均高于对照组的(2.69±2.14)U/ml和(10.01±3.54)IU/ml(P<0.05)。结论 对类风湿关节炎患者抗CCP抗体与RF的诊断敏感度拥有着一定的相似性，但抗CCP抗体特异度高于RF的特异度，若两者联合检测可极大提高敏感度，对于类风湿关节炎患者早期诊断工作的开展拥有着积极的推动作用。
关键词：抗CCP抗体;RF;联合检测;类风湿关节炎;早期诊断;敏感性;特异性
, http://www.100md.com
中图分类号：R593.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.058
文章编号：1006-1959(2019)06-0177-02
Abstract：Objective To explore the significance of combined detection of anti-CCP antibody and RF in the early diagnosis of rheumatoid arthritis. Methods 30 patients with rheumatoid arthritis admitted to our hospital from November 2017 to November 2018 were enrolled as the study group， and 30 healthy controls were selected as the control group. Anti-CCP antibody and RF were administered to the two groups. Combined detection， and analysis of sensitivity， specificity， positive predictive value， and negative predictive value of anti-CCP antibody， RF alone， and a combination of both. Results The positive rate of anti-CCP antibody in the study group was 96.67%， the positive rate of RF was 93.33%， and the positive rate of combined detection was 86.67%， which was higher than 6.67%， 3.33% and 3.33% of the control group. The anti-CCP antibody level of the study group (78.65±14.33) U/ml and RF levels (314.22±20.56) IU/ml were higher than the control group (2.69±2.14) U/ml and (10.01±3.54) IU/ml (P<0.05). Conclusion There is a certain similarity between the anti-CCP antibody and RF diagnostic sensitivity in patients with rheumatoid arthritis， but the specificity of anti-CCP antibody is higher than the specificity of RF. If the combination of the two can greatly improve the sensitivity， for the class The early diagnosis of rheumatoid arthritis patients has a positive role to play.
, http://www.100md.com
Key words：Anti-CCP antibody;RF;Combined detection;Rheumatoid arthritis;Early diagnosis; Sensitivity;Specificity
类风湿性关节炎(rheumatoid arthritis，RA)是一种以炎性滑膜炎为主的系统性疾病，其病因主要与遗传、感染、性激素等因素有紧密的联系，会导致患者晨僵，手足腕踝颞颌关节等关节畸形问题的出现[1]。目前临床上检测类风湿性疾病最常见和较成熟的方法是检查血清中类风湿因子(RF)和抗链球菌溶血素(ASO)。但二者的特异性和敏感性均受某些抗原、抗体物质的干扰，而出现假阳性和假阴性或敏感性不理想[2，3]。而血清中抗CCP抗体的检测是当前检测人员对患者进行检测期间所采取的新型措施，拥有着较高的诊断效率[4]。为此我院将选取的30例类风湿关节炎患者和30例健康体检者进行了诊断方面的研究，现报道如下。, http://www.100md.com(杜敏 李娜)
关键词：抗CCP抗体;RF;联合检测;类风湿关节炎;早期诊断;敏感性;特异性
, http://www.100md.com
中图分类号：R593.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.06.058
文章编号：1006-1959(2019)06-0177-02
Abstract：Objective To explore the significance of combined detection of anti-CCP antibody and RF in the early diagnosis of rheumatoid arthritis. Methods 30 patients with rheumatoid arthritis admitted to our hospital from November 2017 to November 2018 were enrolled as the study group， and 30 healthy controls were selected as the control group. Anti-CCP antibody and RF were administered to the two groups. Combined detection， and analysis of sensitivity， specificity， positive predictive value， and negative predictive value of anti-CCP antibody， RF alone， and a combination of both. Results The positive rate of anti-CCP antibody in the study group was 96.67%， the positive rate of RF was 93.33%， and the positive rate of combined detection was 86.67%， which was higher than 6.67%， 3.33% and 3.33% of the control group. The anti-CCP antibody level of the study group (78.65±14.33) U/ml and RF levels (314.22±20.56) IU/ml were higher than the control group (2.69±2.14) U/ml and (10.01±3.54) IU/ml (P<0.05). Conclusion There is a certain similarity between the anti-CCP antibody and RF diagnostic sensitivity in patients with rheumatoid arthritis， but the specificity of anti-CCP antibody is higher than the specificity of RF. If the combination of the two can greatly improve the sensitivity， for the class The early diagnosis of rheumatoid arthritis patients has a positive role to play.
, http://www.100md.com
Key words：Anti-CCP antibody;RF;Combined detection;Rheumatoid arthritis;Early diagnosis; Sensitivity;Specificity
类风湿性关节炎(rheumatoid arthritis，RA)是一种以炎性滑膜炎为主的系统性疾病，其病因主要与遗传、感染、性激素等因素有紧密的联系，会导致患者晨僵，手足腕踝颞颌关节等关节畸形问题的出现[1]。目前临床上检测类风湿性疾病最常见和较成熟的方法是检查血清中类风湿因子(RF)和抗链球菌溶血素(ASO)。但二者的特异性和敏感性均受某些抗原、抗体物质的干扰，而出现假阳性和假阴性或敏感性不理想[2，3]。而血清中抗CCP抗体的检测是当前检测人员对患者进行检测期间所采取的新型措施，拥有着较高的诊断效率[4]。为此我院将选取的30例类风湿关节炎患者和30例健康体检者进行了诊断方面的研究，现报道如下。, http://www.100md.com(杜敏 李娜)