NT-proBNP对短暂性脑缺血发作患者近期脑卒中风险的预测价值(1)
摘要：目的 探討血清N末端B型利钠肽(NT-proBNP)对短暂性脑缺血发作(TIA)患者近期脑卒中风险的预测价值。方法 回顾性分析2017年2月～2019年5月我院118例确诊为TIA患者的临床资料，将70例1个月内未发生脑卒中者作为对照组，48例发生卒中者作为观察组，按美国国立卫生研究院卒中量表(NIHSS)分为轻度卒中组18例、中度卒中组16例、重度卒中组14例，分析TIA患者发生近期脑卒中的相关影响因素，比较四组NT-proBNP水平。结果 观察组与对照组单侧肢体无力比较，差异无统计学意义(P>0.05);两组同侧颈动脉狭窄≥50%、存在DWI高信号、症状持续时间≥10 min比较，差异有统计学意义(P<0.05)。多因素Logistic回归分析显示，同侧颈动脉狭窄≥50%、存在DWI高信号、症状持续时间≥10 min是TIA患者发生近期脑卒中的独立影响因素(P<0.05)。轻度、中度、重度脑卒中组NT-proBNP水平高于对照组(P<0.05);且随着脑卒中严重程度的加深，NT-proBNP水平不断提升，其中为轻度脑卒中组<中度脑卒中组<重度脑卒中组，差异有统计学意义(P<0.05)。ROC曲线分析显示，NT-proBNP水平对TIA患者近期脑卒中风险预测的曲线下面积分别为0.863、0.905、0.927。结论 短暂性脑缺血脑卒中患者血清NT-proBNP水平随卒中程度的加深而升高，NT-proBNP水平可作为临床预测TIA患者发展为脑卒中的有效指标。
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关键词：N末端B型利钠肽;短暂性脑缺血发作;脑卒中;预测价值
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.24.015
文章编号：1006-1959(2019)24-0047-03
Predictive Value of NT-proBNP in the Risk of Stroke in Patients with Transient Ischemic Attack
QIAN Xiao-juan，XIONG Hua-zhen，YUAN Wen-ting，ZHOU Ru
, 百拇医药
(Department of Laboratory Medicine，Huangmei County People's Hospital，Huangmei 435500，Hubei，China)
Abstract：Objective To investigate the predictive value of serum N-terminal B-type natriuretic peptide (NT-proBNP) on the risk of stroke in patients with transient ischemic attack (TIA). Methods The clinical data of 118 patients diagnosed with TIA in our hospital from February 2017 to May 2019 were retrospectively analyzed. 70 patients without stroke within 1 month were used as the control group， and 48 patients with stroke were used as the observation group. According to the National Institutes of Health Stroke Scale (NIHSS) score， it was divided into 18 patients with mild stroke， 16 patients with moderate stroke， and 14 patients with severe stroke. The related influencing factors of recent stroke in TIA patients were analyzed， and the four groups were compared NT-proBNP levels. Results There was no significant difference in unilateral limb weakness between the control group and observation group(P>0.05); comparing the ipsilateral carotid artery stenosis ≥50%， the presence of high DWI signal， and the duration of symptoms ≥10 min between the two groups were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that ipsilateral carotid artery stenosis ≥50%， high DWI signal， and symptom duration ≥10 min were independent factors affecting stroke in patients with TIA (P<0.05). The NT-proBNP level of mild， moderate， and severe stroke groups was higher than that in control groups (P<0.05); with the deepening of the severity of stroke， the level of NT-proBNP continued to increase， including mild stroke group, http://www.100md.com(钱晓娟 熊华珍 袁雯婷)
, http://www.100md.com
关键词：N末端B型利钠肽;短暂性脑缺血发作;脑卒中;预测价值
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.24.015
文章编号：1006-1959(2019)24-0047-03
Predictive Value of NT-proBNP in the Risk of Stroke in Patients with Transient Ischemic Attack
QIAN Xiao-juan，XIONG Hua-zhen，YUAN Wen-ting，ZHOU Ru
, 百拇医药
(Department of Laboratory Medicine，Huangmei County People's Hospital，Huangmei 435500，Hubei，China)
Abstract：Objective To investigate the predictive value of serum N-terminal B-type natriuretic peptide (NT-proBNP) on the risk of stroke in patients with transient ischemic attack (TIA). Methods The clinical data of 118 patients diagnosed with TIA in our hospital from February 2017 to May 2019 were retrospectively analyzed. 70 patients without stroke within 1 month were used as the control group， and 48 patients with stroke were used as the observation group. According to the National Institutes of Health Stroke Scale (NIHSS) score， it was divided into 18 patients with mild stroke， 16 patients with moderate stroke， and 14 patients with severe stroke. The related influencing factors of recent stroke in TIA patients were analyzed， and the four groups were compared NT-proBNP levels. Results There was no significant difference in unilateral limb weakness between the control group and observation group(P>0.05); comparing the ipsilateral carotid artery stenosis ≥50%， the presence of high DWI signal， and the duration of symptoms ≥10 min between the two groups were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that ipsilateral carotid artery stenosis ≥50%， high DWI signal， and symptom duration ≥10 min were independent factors affecting stroke in patients with TIA (P<0.05). The NT-proBNP level of mild， moderate， and severe stroke groups was higher than that in control groups (P<0.05); with the deepening of the severity of stroke， the level of NT-proBNP continued to increase， including mild stroke group