煤工尘肺合并COPD患者长期规则使用舒利迭的效果(1)
摘要：目的 分析长期规则运用舒利迭对煤工尘肺合并慢性阻塞性肺疾病(COPD)患者的临床疗效。方法 选取2018年3月～2019年3月在本院收治的煤工尘肺合并COPD患者120例为研究对象，采用随机抽样法将其分成对照组和研究组，各60例。对照组采用沙丁胺醇吸入治疗，研究组在对照组的基础上给予舒利迭治疗。比较两组炎症因子水平以及凝血功能。结果 治疗后研究组血清IL-1水平为(123.51±8.57)ρ/μg·L-1，高于对照组的(89.49±8.62)ρ/μg·L-1，而IFN为(125.11±8.37)，低于对照组的(186.36±12.54)，差异具有统计学意义(P<0.05);研究组D-二聚体、Fib、PLT分別为(0.47±0.28)mg/L、(3.78±0.42)g/L、(345.51±62.27)×109/L，低于对照组的(0.86±0.35)mg/L 、(4.58±0.63)g/L、(415.45±53.28)×109/L，差异具有统计学意义(P<0.05)。结论 采用舒利迭治疗煤工尘肺合并COPD疗效满意，有助于改善患者的凝血功能，降低血D-二聚体 、Fib及PLT，提高其血清IL-1水平，值得应用。
关键词：煤工尘肺;COPD;舒利迭
中图分类号：R966 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.04.047
文章编号：1006-1959(2020)04-0147-02
Abstract：Objective To analyze the clinical efficacy of long-term regular application of Seretide in patients with coal worker pneumoconiosis with chronic obstructive pulmonary disease (COPD).Methods A total of 120 patients with coal workers' pneumoconiosis and COPD who were treated in our hospital from March 2018 to March 2019 were selected as the research subjects. They were randomly divided into a control group and a research group， each with 60 patients. The control group was treated with salbutamol inhalation， and the study group was given Seretide therapy on the basis of the control group. The levels of inflammatory factors and coagulation function were compared between the two groups.Results After treatment， the serum IL-1 level in the study group was (123.51±8.57) ρ/μg·L-1， which was higher than that of the control group (89.49±8.62) ρ/μg·L-1， and the IFN was (125.11±8.37)，(186.36±12.54) lower than the control group， the difference was statistically significant (P<0.05); D-dimer， Fib， and PLT in the study group were (0.47±0.28)mg/L， (3.78±0.42 )g/L， (345.51±62.27)×109/L， (0.86±0.35)mg/L， (4.58±0.63)g/L， (415.45±53.28)×109/L lower than the control group，the difference was statistically significant(P<0.05).Conclusion The use of Seretide in the treatment of coal worker pneumoconiosis with COPD is satisfactory， which helps to improve the patient's coagulation function， reduce blood D-dimer， Fib and PLT， and increase its serum IL-1 level， which is worthy of application.
Key words：Coal worker pneumoconiosis;COPD;Long-term;Seretide, 百拇医药(任雨欣)
关键词：煤工尘肺;COPD;舒利迭
中图分类号：R966 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.04.047
文章编号：1006-1959(2020)04-0147-02
Abstract：Objective To analyze the clinical efficacy of long-term regular application of Seretide in patients with coal worker pneumoconiosis with chronic obstructive pulmonary disease (COPD).Methods A total of 120 patients with coal workers' pneumoconiosis and COPD who were treated in our hospital from March 2018 to March 2019 were selected as the research subjects. They were randomly divided into a control group and a research group， each with 60 patients. The control group was treated with salbutamol inhalation， and the study group was given Seretide therapy on the basis of the control group. The levels of inflammatory factors and coagulation function were compared between the two groups.Results After treatment， the serum IL-1 level in the study group was (123.51±8.57) ρ/μg·L-1， which was higher than that of the control group (89.49±8.62) ρ/μg·L-1， and the IFN was (125.11±8.37)，(186.36±12.54) lower than the control group， the difference was statistically significant (P<0.05); D-dimer， Fib， and PLT in the study group were (0.47±0.28)mg/L， (3.78±0.42 )g/L， (345.51±62.27)×109/L， (0.86±0.35)mg/L， (4.58±0.63)g/L， (415.45±53.28)×109/L lower than the control group，the difference was statistically significant(P<0.05).Conclusion The use of Seretide in the treatment of coal worker pneumoconiosis with COPD is satisfactory， which helps to improve the patient's coagulation function， reduce blood D-dimer， Fib and PLT， and increase its serum IL-1 level， which is worthy of application.
Key words：Coal worker pneumoconiosis;COPD;Long-term;Seretide, 百拇医药(任雨欣)