ＨＩＶ－Ａｓｓｏｃｉａｔｅｄ Ｐａｔｈｏｇｅｎｅｓｉｓ： Ｔｈｅ Ｒｏｌｅ ｏｆ ＨＩＶ－1 Ｎｅｆ
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[ABSTRACT]
Since the discovery of HIV more than two decades ago, scientific progress has been impressive and hasdramatically advanced our understanding of HIV infection, from molecular through cellular and then on to systemic pathogenesis,such as the functions of HIV-1 nef gene. However, there is still much to be learned before we fully understand how the hostinteracts with the virus at molecular level and how immune responses correlate with protection from disease. This review describesour current knowledge of HIV/AIDS with the reference of HIV nef functions and its role in HIV-1 mediated pathogenesis.
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