【摘要】目的：探讨人凝血酶原复合物治疗乙型血友病临床效果及用药安全性。方法：抽取我院2019年3月—2022年3月收治的乙型血友病患者20例为研究对象，所有患者均接受人凝血酶原复合物治疗，观察患者凝血因子活性值及凝血功能变化情况，并评估两组治疗效果及安全性。结果：①20例患者治疗30min后凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ活性值显著高于治疗前(P<0.05)；②20例患者治疗1d后凝血功能指标FIB、PT、TT、APTT水平均显著优于治疗前(P<0.05)；③20例患者治疗总有效率为100.00%。结论：针对乙型血友病患者，予以人凝血酶原复合物治疗，可提高患者体内凝血因子活性，缓解患者凝血功能障碍，提高治疗效果，且该药物不良反应少、安全性高，值得推广。

    【关键词】乙型血友病；人凝血酶原复合物；疗效；安全性

    Evaluation of the efficacy and safety of human prothrombin complex in the treatment of hemophilia B

    LONG Haiying， ZHANG Jun

    The Second Affiliated Hospital of Guizhou Medical University， Kaili， Guizhou 556000， China

    【Abstract】Objective： To explore the clinical efficacy and medication safety of human prothrombin complex in the treatment of hemophilia B. Methods： Twenty patients with hemophilia B admitted to our hospital from March 2019 to March 2022 were selected as the study subjects. All patients received treatment with human prothrombin complex， and the activity values of coagulation factors and changes in coagulation function were observed. The treatment effects and safety of the two groups were evaluated. Results： ① After 30 minutes of treatment ......