中图分类号：R255.4 文献标志码：A 文章编号：1007-2349(2025)07-0089-06

    Research Progress on the Mechanism of Traditional Chinese Medicine Regulating the PI3K/Akt Signaling Pathway in the Prevention and Treatment of Diabetic Cognitive Impairment

    ZHANG Zi-peng，LUO Yu- wen，AN Dong，LIANG Yong-lin，LIN Xin - jie， CHAI Chao(Gansu UniversityofTraditional ChineseMedicine，Lanzhou73oooo，China)

    【AbstractDiabetes isan important risk factor for cognitive impairment.The mechanisms of the association betwendiabetesandcognitive impairment include insulin resistance，mitochondrial autophagy，inflammation，oxidative stress，etc.In recent years，a large number of studies have found thatthe phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway isan important targetfortheprevention and treatment of diabeticcognitivedysfunction(DCD).Monomers and compound prescriptions of traditional Chinese medicine affect mammalian target of rapamycin( mToR)， glycogen synthase kinase ^-3(GSK-3β) ， superoxide dismutase( SOD)， postsynaptic density protein -95 (PSD -95)，apoptosis inhibitor gene(Bcl -2) ......