UsingofantibioticsinPatientswithTumor(1)
【Abstract】 Antibiotics are the most widely used clinical drugs, is one of important income source of the hospital. Improper use of antibiotics not only increased drugs' adverse reactions, also the important reasons for leading to the continuous generation of drug-resistant strains. With the development of cancer therapeutics, infection has become the most common complication of cancer patients and the cause of death. Therefore, rational application of antibiotics in cancer patients has an important role for reducing cancer mortality.
【Keywords】antibioticdrug usingthe type of drug use
【中图分类号】 R917【文献标识码】 B【文章编号】 1007-8231(2011) 08-0661-03
A large number of antibiotics are applied in clinical treatment. Because of its large amount ofuse and variety, a lot of problems in clinical use exist. Therefore rational use of antibiotics has become the focus of attention. To understand the use of antibiotics in patients with tumor in hospital, enhance the clinical drug safety, effectiveness and legitimacy, and provide the basis for the rational use of antibiotics, this article did a investigation on use of antibiotics in hospitalized patients in our hospital.
I.the principles of antibiotic using in the treatment of cancer patients
For cancer patients, antibiotics is effective for bacterial infections also for infections caused by mycoplasma, anti-Rickettsia, actinomycetes and fungi. Before treatment,we should understand the nature of the source of infection and drug sensitivity. Molecular biology techniques (such as polymerase chain reaction) completely changed the diagnosis of infectious diseases and is helpful to developing treatment programs.Treatment based on clinical diagnosis, laboratory diagnosis, the patient's economic status and social factors. Viral infection and fever of unknown cause should not use antibiotics, because typical clinical manifestations and pathogenic bacteria can not easily be found after the application which may delay proper diagnosis and treatment. Combination therapy should be strict in indications. Treatment should use only one antibiotic as far as possible in narrow area, antibiotics can be combined only in rare cases: pathogens of serious infections has not been clear; patients’ situation can not be controled the infection with a mixture of antibiotics; single antibiotic can not effectively control severe Pseudomonas aeruginosa infections, bacterial endocarditis, etc.; bacteria may produce long-term drug resistance, urinary tract infections such as tuberculosis. The case that the site of infection is not easy to penetrate of antibiotics is very difficult to cure, such as bacteria meningitis. Combined use of antibiotics can achieve synergy and delayed effects of the medicine.
In reducing the toxicity of effective antibiotics and effective antibiotic inactivation, such as the lactam and aminoglycoside antibiotics in combination, can produce synergy. Rational use of antibiotics must be chosen under a clear indication of appropriate drugs, use appropriate formulations and treatment in order to kill pathogenic micro-organisms and control infection. Tumor patient immune dysfunction, prone to microbial infection, particularly bacterial infection mainly, if not based on susceptibility testing use of antibiotics, it can causes the body dysbacteriosis easily, the occurrence of double infection increased disease, severe cases can lead to death. So for tumor patients, the use of antibiotics and the choice are particularly important.。At the same time take appropriate measures to increase the patient's immune system and prevent undesirable consequences., 百拇医药(LIU Kun)
【Keywords】antibioticdrug usingthe type of drug use
【中图分类号】 R917【文献标识码】 B【文章编号】 1007-8231(2011) 08-0661-03
A large number of antibiotics are applied in clinical treatment. Because of its large amount ofuse and variety, a lot of problems in clinical use exist. Therefore rational use of antibiotics has become the focus of attention. To understand the use of antibiotics in patients with tumor in hospital, enhance the clinical drug safety, effectiveness and legitimacy, and provide the basis for the rational use of antibiotics, this article did a investigation on use of antibiotics in hospitalized patients in our hospital.
I.the principles of antibiotic using in the treatment of cancer patients
For cancer patients, antibiotics is effective for bacterial infections also for infections caused by mycoplasma, anti-Rickettsia, actinomycetes and fungi. Before treatment,we should understand the nature of the source of infection and drug sensitivity. Molecular biology techniques (such as polymerase chain reaction) completely changed the diagnosis of infectious diseases and is helpful to developing treatment programs.Treatment based on clinical diagnosis, laboratory diagnosis, the patient's economic status and social factors. Viral infection and fever of unknown cause should not use antibiotics, because typical clinical manifestations and pathogenic bacteria can not easily be found after the application which may delay proper diagnosis and treatment. Combination therapy should be strict in indications. Treatment should use only one antibiotic as far as possible in narrow area, antibiotics can be combined only in rare cases: pathogens of serious infections has not been clear; patients’ situation can not be controled the infection with a mixture of antibiotics; single antibiotic can not effectively control severe Pseudomonas aeruginosa infections, bacterial endocarditis, etc.; bacteria may produce long-term drug resistance, urinary tract infections such as tuberculosis. The case that the site of infection is not easy to penetrate of antibiotics is very difficult to cure, such as bacteria meningitis. Combined use of antibiotics can achieve synergy and delayed effects of the medicine.
In reducing the toxicity of effective antibiotics and effective antibiotic inactivation, such as the lactam and aminoglycoside antibiotics in combination, can produce synergy. Rational use of antibiotics must be chosen under a clear indication of appropriate drugs, use appropriate formulations and treatment in order to kill pathogenic micro-organisms and control infection. Tumor patient immune dysfunction, prone to microbial infection, particularly bacterial infection mainly, if not based on susceptibility testing use of antibiotics, it can causes the body dysbacteriosis easily, the occurrence of double infection increased disease, severe cases can lead to death. So for tumor patients, the use of antibiotics and the choice are particularly important.。At the same time take appropriate measures to increase the patient's immune system and prevent undesirable consequences., 百拇医药(LIU Kun)