基于NF-κB_TLR4(实验研究)

基于NF-κB/TLR4/Nrf2信号通路探讨钩藤-天麻药对治疗药物性肝损伤的作用及机制

http://www.100md.com 2025年7月22日中国民族民间医药·下半月 2025年第5期

     【中图分类号】R285.5 【文献标志码】A 【文章编号】1007-8517(2025)10-0034-06

    DOI： 10.3969/j .issn.1007-8517.2025.10. zgmzmjyzz202510007

    Effect and Mechanism of Uncaria Rhynchophylla -Gastrodia ElataHerb -Pair on Drug-Induced Liver Injury Based on NF-κB/μLR4/νNrf2 Signaling Pathway

    PANG Ting1LI Junxuan2MA Liuhui1WANG Zhihao3HE Huan1QIN Qingxia1* 1.Guangxi Agricultural Vocational University，Nanning 530o07，China；2.Nanning HealthSchol，Nanning 530028，China; 3.Guangxi Baicao Zhenxing Agricultural Science and Technology Co.，Ltd，Yulin 537Ooo，China

    Abstract：Objective Toexplore theefectandmolecularmechanismof Uncariarhynchophylla-Gastrodiaelata herb-pair inthe treatment of drug-induced liver injury caused by Tripterygium glycosides tablets through NF-κB/ΩTLR4/ΩNrf2 signaling pathway. MethodsMale SPFBALB/c mice wererandomlydivided intosix groups，including threeUncariarhynchophyll-Gastrodia elata herb - pairgroups ( the doses were 8.12 5g?kg^-1d^-1

and 32.500g?kg^-1?d^-1 ......

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