【摘要】 抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一种自身免疫性脑炎，是卵巢畸胎瘤的罕见并发症之一，主要治疗方式为手术切除肿瘤联合免疫治疗，但卵巢畸胎瘤相关抗NMDAR脑炎的发病机制目前尚不明确，且患者临床表现多样，多以神经系统表现为主，易误诊及漏诊，需妇科和神经内科医生共同诊断及治疗。本文综述了NMDAR的结构和功能，归纳了既往卵巢畸胎瘤相关抗NMDAR脑炎的相关研究成果，总结其发病机制、早期诊断、鉴别诊断、治疗、预后和复发的研究进展，为更好地诊断和治疗卵巢畸胎瘤相关抗NMDAR脑炎提供理论依据和思路。

    【关键词】 抗N-甲基-D-天冬氨酸受体脑炎；畸胎瘤；抗NMDAR受体；发病机制

    【中图分类号】 R 739.4 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2023.0363

    Advances in Pathogenesis，Diagnosis and Treatment of Ovarian Teratoma Associated Anti-N-methyl-D-aspartate Receptor Encephalitis

    ZHANG Shan1，ZHANG Meng1，XU Xin1，LIAO Lixin1，SUN Mingjun1，MA Haiyan1，ZHANG Haibin2，GUO Yuzhen2*

    1.Second Clinical Medical College，Lanzhou University，Lanzhou 730030，China

    2.Department of Gynecology，Lanzhou University Second Hospital，Lanzhou 730030，China

    *Corresponding author：GUO Yuzhen，Professor；E-mail：guoyz@lzu.edu.cn

    【Abstract】 Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis that is a rare complication of ovarian teratoma. The primary treatment is surgical resection of the tumor combined with immunotherapy ......