【摘要】 糖尿病足溃疡(DFU)通常伴有不同程度的周围神经病变和血管病变，是一种难愈合创面，其愈合延迟过程主要是有新血管再生障碍、持续的创面炎症反应、创面再上皮化障碍及成纤维细胞增殖异常。外泌体微小RNA(miRNA)作为细胞间通讯的重要介质，参与多种生物学过程，可调控影响DFU愈合的多种靶基因转录翻译。本文旨在简要综述外泌体miRNA对新血管再生、炎症反应、创面再上皮化功能以及成纤维细胞增殖功能在DFU修复中的调控作用，以期为DFU的治疗提供新思路。

    【关键词】 糖尿病足溃疡；外泌体；微小核糖核酸；综述

    【中图分类号】 R 587.42 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2024.0342

    Research Progress of Exosome miRNA Involved in the Repair of Diabetic Foot Ulcer

    CEN Nimiao1，2，WEI Yunshi2，HUANG Lina1，2，WU Biaoliang1*

    1.Department of Endocrinology，Affiliated Hospital of Youjiang Medical University for Nationalities，Baise 533000，China

    2.Graduate School of Youjiang Medical University for Nationalities，Baise 533000，China

    *Corresponding author：WU Biaoliang，Chief physician/Doctoral supervisor；E-mail：yymucun@ymun.edu.cn

    【Abstract】 Diabetic foot ulcer(DFU)is usually accompanied by varying degrees of peripheral neuropathy and vasculopathy. It is a difficult-to-heal wound. The delayed healing process is mainly due to new blood vessel regeneration disorder ......