血液灌流治疗重度有机磷农药中毒肝损害的临床疗效(1)
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摘要：目的：探讨血液灌流对急性重度有机磷农药中毒患者肝损害的临床疗效。
方法：将60例急性重度有机磷中毒患者随机分为血液灌流组与非灌流组，观察两组患者入院72小时后肝功能、血清胆碱酯酶变化情况。
结果：两组患者在性别、年龄、血浆有机磷含量、就诊时间上无统计学差异(P>0.05)；非血液灌流组患者死亡率高于灌流组(P<0.05)；血液灌流组在入院后72h肝功能及胆碱酯酶恢复明显快于非灌流组，两组具有显著性差异。
结论：血液灌流治疗可促进急性重度有机磷农药中毒患者肝功能及血清胆碱酯酶的恢复，是一种有效的治疗手段。
关键词：有机磷中毒 血液灌流 肝损害
The effect of hemoperfusion on hepatic lesion in patients with severe organophosphate poisoning
Yang Xumei Xiao Lu
Abstract:Objective:To investigate the curative effect of hemoperfusion on hepatic lesion in patients with severe organophosphate poisoning.
Methods:The 60 cases of severe acute organophosphate poisoning were divided into hemoperfusion group and non-hemoperfusion group, the changes of liver function 、serum cholinesterase of both groups were observed after 72 hours.
Result:There is no significant difference between two group in sex、age、organophosphate content and serum cholinesterase(P>0.05)；The case fatality rate of non-hemoperfusion group is higher than hemoperfusion group(P<0.05)；the liver function and serum cholinesterase recovered quickly in hemoperfusion group at 72h, there is a significant difference between two groups.
Conclusion:Hemoperfusion can alleviate the liver function damage of acute organophosphate poisoning and promote the recovery of serum cholinesterase, it is an effective method for organophosphate poisoning.
Keywords:Organophosphate poisoning Hemoperfusion Hepatic lesion
【中图分类号】R595.4【文献标识码】 【文章编号】1008-1879(2012)07-0036-02
有机磷杀虫药主要抑制体内胆碱酯酶，使乙酰胆碱蓄积，引起胆碱能神经先兴奋后抑制的一系列毒蕈碱样、烟碱样和中枢神经系统症状，严重者可出现昏迷、多脏器功能衰竭而死亡。肝脏受损在有机磷中毒时尤为显著，单纯的保肝药物治疗临床疗效差。我院采用血液灌流治疗急性重度有机磷中毒60例患者，取得较好疗效，现就其对肝脏保护作用报道如下。
1 资料与方法
1.1 临床资料。选取2007年8月—2011年10月就诊于内蒙古鄂尔多斯市中心医院的急性重度有机磷中毒患者60例 ......
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