ＲＮＡ干扰技术及其应用
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摘要: RNA干扰(RNAi)是双链RNA(double-stranded RNA，dsRNA)分子，能高效、特异阻断靶基因，使细胞表现出转录后水平的基因沉默(post transcriptional gene silencing，PTGS)。笔者对RNAi的发现、作用机制、应用和发展前景进行了探讨。
关键词: RNA干扰;基因沉默;作用机制
中图分类号:Q522
文献标识码:A
文章编号:1008-2409(2004)06-1036-03
RNA interference technique/XU Jing//The Affiiated Hospital of Guilin Medical College，Guilin541001，China
Abstract:RNA interference(RNAi)is a form of post transcriptional gene silencing.It is characterized by a number of features:inducted by double stranded RNA(dsRNA)，a high degree of specificity and a sustained down-regulation of the target gene.The discovery，mechanism and prospect of RNA are summarized in this paper.Key words:RNA interference;gene silencing;mechanism
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