斯丽凯纳米银抗菌凝胶治疗慢性溃疡的临床观察(1)
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[摘要]目的：观察斯丽凯纳米银抗菌凝胶治疗慢性溃疡的临床疗效。方法：试验组：选取慢性溃疡患者50例进行临床试验，应用斯丽凯纳米银抗菌凝胶进行创面换药。对照组：设自身同体对照，慢性溃疡面积相近、相邻或部位对称，应用磺胺嘧啶银乳膏换药。观测记录各组病例不同时相点的创面疼痛程度、创面渗出液、创面水肿程度、创面有效率、细菌培养率和药物不良反应。结果：试验组不同时相点的创面疼痛程度和创面渗出液明显小于对照组(P<0.05)；试验组不同时相点的创面水肿程度与对照组的差异无统计学意义(P>0.05)；试验组不同时相点的创面有效率明显高于对照组(P<0.05)；试验组不同时相点的细菌检出率明显低于对照组(P<0.05)，试验组应用斯丽凯纳米银抗菌凝胶后未见明显不良反应。结论：斯丽凯纳米银抗菌凝胶治疗慢性溃疡有较好的抗菌及促进创面修复的作用，能有效缩短溃疡创面的愈合时间。
[关键词]纳米银抗菌凝胶；慢性溃疡；创面治疗
[中图分类号]R644[文献标识码]A[文章编号]1008-6455(2011)05-0728-04
Observation of therapeutic effect of SilverCare nanometer silver antimicrobial gel on chronic ulcers
ZHANG Long,CUI Zheng-jun,HAN Zhao-feng,ZHOU Jian,ZHANG Shu-tang
(Department of Burn and Repair Reconstruction Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)
Abstract:0bjectiveTo observe the therapeutic effect of SilverCare nanometer silver antimicrobial gel on Chronic ulcers.MethodsTrial group: To select 50 patients with chronic ulcer,and take silvercare nanometer silver gel to change dressings. Control group: Self-contral observation was used on the same patient with chronic ulcer,which scattered on adjacent or symmetrical parts of bodies,and taked sulfadiazine silver cream.Data was collected at different time points on wound pain,wound exudate,wound edema,wound effective rate,bacterial culture rate,and adverse drug reactions.ResultsWound painand wound edema in trial group were significantly lower than those of control group at different time pionts (P<0.05); wound exudate in trial group was not significantly lower than those of control group at different time pionts (P>0.05); wound effective rate of trial group was obviously higher than those of control group (P<0.05);and bacterial culture rate of trial group was evidently lower than those of control group (P<0.05);the obvious adverse reactions were not observed in trial group.ConclusionsSilverCare nanometer silver antimicrobial gel has better antibacteriaI activity, promotes wound management,and decreases the healing time,comparing with sulfadiazine silver cream.
Key words:nanometer silver gel; chronic ulcers; wound management ......
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