浓替硝唑含嗽液治疗糖尿病患者慢性牙周炎临床疗效观察(1)
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[摘要]目的：观察浓替硝唑含嗽液对糖尿病患者慢性牙周炎的临床疗效。方法：74例2型糖尿病并发慢性牙周炎患者随机分为2组，对照组(n=36)采用基础治疗，实验组(n=38)在基础治疗基础上加浓替硝唑含嗽液治疗，疗程2周。观察治疗前后患者牙周指标的变化。结果：两组患者治疗前菌斑指数(PLI)、牙周探针深度(PD)、附着水平丧失(AL)、牙齿松动度(TM)均无明显差异(P>0.05)。对照组治疗前后比较，PLI、PD、AL、TM均无统计学上显著差异。实验组治疗后PD、AL、TM与治疗前相比，差异显著(P<0.01)。实验组干预治疗后与对照组比较，PD、AL、TM亦有统计学上显著意义差异(P<0.01)，不良反应发生率与对照组相似。结论：浓替硝唑含嗽液可以明显改善糖尿病患者牙周基础治疗后的疗效，不良反应发生率低于口服和注射给药。
[关键词]浓替硝唑含嗽液；糖尿病；牙周炎；疗效
[中图分类号]R783 [文献标识码]A [文章编号]1008-6455(2011)05-0829-02
Clinical investigation on effects of concentrated tinidazole gargles in 74 diabetic patients with periodontitis
YAN Da-jun
(Department of Stomatology,309th Hospital of PLA,Beijing 100091,China)
Abstract:ObjectiveTo investigate clinical efficiencyand safety of concentrated tinidazole gargles in diabetic patients with periodontitis. Methods 74 diabetic patients with periodontitis were selected and divided into experimental group(n=38) and control group randomly. Experimental group were treated with concentrated tinidazole gargles besides conventional oral treatment for two weeks,while control group received conventional oral treatment only.The changes of periodontal indexes such as plaque index(PLI), teeth probing depth(PD),attaching loss(AL),and teeth mobility(TM) were observed before and after treatment. ResultsBefore treatment, the PLI,PD,AL and TM values in two groups showed no difference. After treatment, the PLI,PD,AL and TM values in experimental group significantly improved compared with baseline (P<0.01), they also show significant difference compared with control group(P<0.01),while with similar safety. ConclusionConcentrated tinidazole gargles might be an effective and safe way in the prevention of periodontitis in diabetic patients.
Key words:concentrated tinidazole gargles;diabetes mellitus;periodontitis;efficiency
糖尿病(DM)是一种最为常见的代谢紊乱综合征，近年来DM患病率呈逐年上升趋势，老年DM患者常发生多种慢性并发症。DM与口腔健康的关系密切，DM患者因其内分泌和代谢紊乱，微循环病变，免疫功能低下等因素，导致牙周微循环障碍，促进牙周炎的发生[1-2]。DM患者同时患有口腔疾病者高达87.3%，约为正常人患病率的2～3倍[3]。牙周病是DM常见的并发症[4]，也是导致成人牙齿丧失的主要原因之一。对于DM患者牙周病的治疗，单纯的抗菌、牙周局部治疗难以达到理想的效果。近年来，国内外众多的文献报道了替硝唑在口腔科抗感染中的治疗作用[5]。由于替硝唑口服制剂的不良反应相对局部用药多见。本研究应用浓替硝唑含嗽液辅助治疗2型DM患者的慢性牙周炎，取得了较理想的疗效。现报道如下。
1 资料和方法 ......
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