雌激素受体亚型在肥大乳房乳腺组织中的表达及意义(1)
 |
| 第1页 |
参见附件(2364KB，3页)。
[摘要]目的：研究雌激素受体亚型α和β(ERα和ERβ)在肥大乳房乳腺组织中和正常体积乳房乳腺组织中的表达，探讨其在乳房肥大发病机制中的作用和意义。方法：采用免疫组织化学EnVision二步法，测定38例肥大乳房和17例正常体积乳房中ERα和ERβ的表达情况。结果：ERα在肥大乳房和正常体积乳房中的阳性表达率分别为97.37%和76.47%，两者比较差异具有统计学意义(P<0.05)。ERβ在肥大乳房和正常体积乳房中的阳性表达率分别为89.47%和100%，两者比较差异无统计学意义(P>0.05)。结论：乳房肥大的发生可能与乳腺组织中ERα含量升高有关，与ERβ无明显相关性。
[关键词]雌激素受体α；雌激素受体β；乳房肥大
[中图分类号]R730 [文献标识码]A [文章编号]1008-6455(2012)03-0431-03
Expression of estrogen receptor isoforms in the mammary gland of the hypertrophic breast and its significance
ZHANG Rui-rui1,JIN Jun-hua1,SUN Jia-ming2
(1.Department of Plastic Surgery,The Central Hospital of Xiangyang,Xiangyang 441021,Hubei,China 2. Department of Plastic Surgery,Union Uospital,Tongji Medical College,Huazhong University of Science and Technology)
Abstract： Objective To detect the expression of the estrogen receptor(ER) isoforms(ERα and ERβ)in the mammary gland of the hypertrophic breast and the normal voluminal breast,so that their function and significance in the pathogenesis of breast hypertrophy can be investigated. Methods The breast tissue samples were obtained,including hypertrophic breast tissue(38 cases) and normal voluminal breast tissue(17 cases).They were detected by the EnVision two step method immunohistochemistry for the expression of ERα and ERβ. Results The positive expression rate of ERα in the hypertrophic breast was 97.37%,while 76.47% in the normal voluminal breast,showing a significant difference between the two groups(P<0.05). The positive expression rates of ERβ in the hypertrophic breast and normal voluminal breast were 89.47% and 100%,and showing no significant difference between them(P>0.05). Conclusions The development of hypertrophic breast may be related to the excessive expression of ERα in the breast tissue,while the relationship between the hypertrophic breast and ERβ may be not obvious.
Key words:ERα；ERβ；hypertrophic breast
近几十年来，国内外在乳房肥大的病因学方面进行了很多有意义的研究，普遍认为，一方面可能与乳腺组织局部雌激素增多有关，另一方面可能是由于靶细胞对雌激素的敏感性增强[1]。而靶细胞敏感性的增强主要同乳房中的雌激素受体相关，孙家明[2]等人的研究表明肥大乳房乳腺组织中的雌激素受体较正常乳房增多。乳房中存在两种雌激素受体亚型，雌激素受体亚型α和β(ERα和ERβ)。乳房肥大的发生同这两种亚型有着怎样的关系，目前尚无人研究 ......
您现在查看是摘要介绍页，详见PDF附件(2364KB，3页)。