[摘要]目的：探讨维吾尔药异常黑胆质成熟剂总黄酮(Abnormal savda munziq-total flavonoids，ASMq-TF)对体外培养的增生性瘢痕成纤维细胞(Hypertrophic scar fibroblasts，HFs)增殖抑制作用及对相关胶原蛋白合成的影响。方法：对HFs进行体外培养并给予不同浓度的ASMq-TF处理，然后，通过CCK-8检测其细胞增殖情况，通过RT-PCR和Western blot实验检测相关胶原蛋白表达。结果：ASMq-TF能够显著抑制HFs的增殖及抑制胶原蛋白的表达。讨论：本实验结果表明ASMq-TF通过促进SMAD7合成及减少CollagenⅠ分泌等抑制HFs增殖。

    [关键词]异常黑胆质成熟剂总黄酮；增生性瘢痕；成纤维细胞；体外培养；胶原蛋白；增殖

    [中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455(2015)23-0031-05

    Abstract： Objective To evaluate in vitro effect of Abnormal savda munziq-total flavonoids on the proliferation and collagen synthesis of human hypertrophic scar fibroblasts(HFs). Methods HFs was cultured in vitro and treated with different concentrations of ASMq-TF.Then ......