手术切除联合多磺酸粘多糖治疗耳廓瘢痕疙瘩疗效观察(1)
[摘要]目的：探讨耳廓瘢痕疙瘩切除术联合多磺酸粘多糖对耳廓瘢痕疙瘩的治疗效果。方法：选择2007年3月-2017年11月笔者医院收治的114例耳廓瘢痕疙瘩患者作为研究对象，按照随机数字表法分为观察组和对照组，每组57例。两组均实施耳廓瘢痕疙瘩切除术，观察组在此基础上配合使用多磺酸粘多糖乳膏，2次/d。比較两组临床疗效、瘢痕病灶温哥华瘢痕量表(Vancouver scar scale，VSS)评分以及复发和感染发生情况。结果：观察组治疗有效率为87.71%，明显高于对照组的75.44%，差异有统计学意义(P<0.05)。两组患者治疗后1、6个月的VSS评分较治疗前明显下降，观察组优于对照组，差异有统计学意义(P<0.05)。两组患者的感染和复发率比较，差异无统计学意义(P>0.05)。结论：耳廓瘢痕疙瘩切除术配合多磺酸粘多糖可明显提高临床疗效，减少复发和感染率，值得临床推广应用。
[关键词]瘢痕疙瘩；耳廓；多磺酸粘多糖乳膏；切除术；疗效
[中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455(2018)05-0001-03
, http://www.100md.com
Curative Effect of Surgical Resection Combined with Mucopolysaccharide Polysulfate in the Treatment of Auricular Keloid
LI Jing，WU Xin-feng
(Department of Plastic Surgery，Hospital for Skin Diseases， Chinese Academy of Medical Sciences，Peking Union Medical College，Nanjing 210042，Jiangsu，China)
Abstract： Objective To observe and analyze the effect of auricle keloid resection combined with mucopolysaccharide polysulfate on auricular keloid. Methods A total of 114 patients with auricle keloids treated in our hospital from March 2007 to November 2017 were selected as study subjects and divided into the observation group and the control group according to random number table， 57 cases in each group. The patients underwent auricle keloid incision according to different conditions of auricle scar. The patients in the observation group were treated with mucopolysaccharide polysulfate cream after operation， twice daily. The clinical curative effect， scarring scars of vancouver scar scale (VSS) score， relapse and infection rate of the two groups were observed and analyzed. Results The effective rate of the observation group was 87.71%， significantly higher than that of the control group (75.44%)， the difference was statistically significant(P<0.05). The VSS scores of the two groups at 1 and 6 months after treatment were significantly lower than those before treatment， the observation group was superior to the control group(P<0.05). There was no significant difference in the infection rate and recurrence rate between the two groups(P>0.05). Conclusion Auricular keloid resection combined with mucopolysaccharide polysulfate cream can significantly improve the clinical efficacy and reduce the recurrence and infection rate， it is worth promoting the use of the clinic.
, 百拇医药
Key words： keloid； auricle； mucopolysaccharide polysulfate cream； resection； curative effect
耳廓瘢痕疙瘩主要是由于耳廓穿刺，如耳钉佩戴、耳廓外伤引起的感染造成耳廓皮肤纤维组织过度增生，多见于18～40岁的女性，瘢痕疙瘩表现为结缔组织增生和透明变形并形成超过原有损害范围的瘢痕扩大，刺痛和瘙痒感觉明显[1]。目前耳廓瘢痕疙瘩主要通过切除手术和糖皮质激素注射进行治疗，虽然治疗后疗效显著，但临床数据显示整体复发率较高，同时术后极易出现耳廓外缘不全，对患者容貌具有较大影响，增加其心理负担和焦虑[2-3]。研究表明相较于糖皮质激素，多磺酸粘多糖软膏对瘢痕具有明显的软化和抑制效用，可加速伤口愈合。本次研究采用耳廓瘢痕疙瘩切除术配合多磺酸粘多糖软膏进行治疗，并行对比分析，现报道如下。, http://www.100md.com(李静 吴信峰)
[关键词]瘢痕疙瘩；耳廓；多磺酸粘多糖乳膏；切除术；疗效
[中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455(2018)05-0001-03
, http://www.100md.com
Curative Effect of Surgical Resection Combined with Mucopolysaccharide Polysulfate in the Treatment of Auricular Keloid
LI Jing，WU Xin-feng
(Department of Plastic Surgery，Hospital for Skin Diseases， Chinese Academy of Medical Sciences，Peking Union Medical College，Nanjing 210042，Jiangsu，China)
Abstract： Objective To observe and analyze the effect of auricle keloid resection combined with mucopolysaccharide polysulfate on auricular keloid. Methods A total of 114 patients with auricle keloids treated in our hospital from March 2007 to November 2017 were selected as study subjects and divided into the observation group and the control group according to random number table， 57 cases in each group. The patients underwent auricle keloid incision according to different conditions of auricle scar. The patients in the observation group were treated with mucopolysaccharide polysulfate cream after operation， twice daily. The clinical curative effect， scarring scars of vancouver scar scale (VSS) score， relapse and infection rate of the two groups were observed and analyzed. Results The effective rate of the observation group was 87.71%， significantly higher than that of the control group (75.44%)， the difference was statistically significant(P<0.05). The VSS scores of the two groups at 1 and 6 months after treatment were significantly lower than those before treatment， the observation group was superior to the control group(P<0.05). There was no significant difference in the infection rate and recurrence rate between the two groups(P>0.05). Conclusion Auricular keloid resection combined with mucopolysaccharide polysulfate cream can significantly improve the clinical efficacy and reduce the recurrence and infection rate， it is worth promoting the use of the clinic.
, 百拇医药
Key words： keloid； auricle； mucopolysaccharide polysulfate cream； resection； curative effect
耳廓瘢痕疙瘩主要是由于耳廓穿刺，如耳钉佩戴、耳廓外伤引起的感染造成耳廓皮肤纤维组织过度增生，多见于18～40岁的女性，瘢痕疙瘩表现为结缔组织增生和透明变形并形成超过原有损害范围的瘢痕扩大，刺痛和瘙痒感觉明显[1]。目前耳廓瘢痕疙瘩主要通过切除手术和糖皮质激素注射进行治疗，虽然治疗后疗效显著，但临床数据显示整体复发率较高，同时术后极易出现耳廓外缘不全，对患者容貌具有较大影响，增加其心理负担和焦虑[2-3]。研究表明相较于糖皮质激素，多磺酸粘多糖软膏对瘢痕具有明显的软化和抑制效用，可加速伤口愈合。本次研究采用耳廓瘢痕疙瘩切除术配合多磺酸粘多糖软膏进行治疗，并行对比分析，现报道如下。, http://www.100md.com(李静 吴信峰)
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