[摘要]目的：评价30%超分子水杨酸联合盐酸米诺环素治疗中重度痤疮的临床疗效和安全性。方法：选取笔者医院就诊的80例中重度痤疮患者，采用随机数字表法分为治疗组和对照组，其中治疗组40例，给予30%超分子水杨酸联合口服盐酸米诺环素治疗，对照组40例，外用0.1%阿达帕林凝胶联合口服盐酸米诺环素治疗，分别对两组患者进行临床疗效评估，同时记录治疗期间出现的不良反应。结果：治疗8周后，治疗组有效率为92.05%，对照组为70.00%，两组比较差异有统计学意义(P<0.05)，两组均未发生严重不良反应。结论：30%超分子水杨酸联合口服盐酸米诺环素治疗中重度痤疮，安全有效，副作用小，值得临床推广。

    [关键词]30%超分子水杨酸;中重度痤疮;盐酸米诺环素;阿达帕林凝胶;疗效;不良反应

    [中图分类号]R758.73+1 [文献标志码]A [文章编号]1008-6455(2019)04-0042-03

    Abstract： Objective To evaluate the clinical efficacy and safety of 30% supramolecular salicylic acid combined with minocycline hydrochloride in the treatment of moderate to severe acne vulgaris. Methods 80 patients with moderate to severe acne who were treated in our hospital were selected as subjects. They were divided into two groups by random number table method. 40 patients in the treatment group were treated with 30% supramolecular salicylic acid combined with oral minocycline hydrochloride ......