[摘要]目的：分析果酸换肤联合蜂巢皮秒激光治疗黄褐斑的疗效。方法：收集2021年3月-2023年2月笔者医院医疗美容科确诊黄褐斑女性患者62例，随机分为对照组(n=31)和研究组(n=31)，两组均采用蜂巢皮秒激光治疗3次，研究组在激光治疗基础上，两周后再行果酸换肤治疗。比较两组患者治疗前、治疗后4周及治疗后12周黄褐斑面积及严重程度指数(MASI)评分、下降率、复发率、总有效率、患者满意度及不良反应。结果：治疗后4周，两组患者MASI评分均较治疗前降低(P<0.05)；研究组MASI评分低于对照组，下降率及总有效率高于对照组(P<0.05)；治疗后12周研究组复发率低于对照组(P<0.05)；研究组满意率高于对照组(P<0.05)；研究组不良反应发生率与对照组比较，差异无统计学意义(P>0.05)。结论：果酸换肤联合蜂巢皮秒激光治疗黄褐斑的MASI评分下降率和总有效率高，且复发率低，临床疗效显著，患者满意度高，值得临床推广应用。

    [关键词]黄褐斑；果酸；蜂巢皮秒激光；临床疗效

    [中图分类号]R758.42" " [文献标志码]A" " [文章编号]1008-6455(2025)08-0117-04

    Analysis of Curative Effect of Fruit Acid Peels Combined with Honeycomb Picosecond Laser in the Treatment of Melasma

    MENG Yu， LIN Di

    ( Department of Medical Aesthetics， Si'an Hospital， Dongguan 523000， Guangdong， China )

    Abstract： Objective" To explore and analyze the curative effect of fruit acid peels combined with honeycomb picosecond laser in the treatment of melasma. Methods" From March 2021 to February 2023， 62 female patients with chloasma were collected and randomly divided into control group (n=31) and research group (n=31). Both groups were treated with honeycomb picosecond laser for three times ......