几丁糖对扩张后皮瓣纤维包膜厚度影响的临床研究(1)
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(河北大学附属医院 河北 保定 071000)
【摘要】目的：在临床实践中应用几丁糖干预扩张后皮瓣纤维包膜的形成过程，观察应用前后纤维包膜厚度，为临床探索一种能减少扩张后皮瓣纤维薄膜厚度，从而减轻其弹性回缩作用的可行方法。方法：2006年以来，每个患者同时应用二个扩张器修复病变，共对24例患者行皮肤软组织扩张术，每个患者均在病变周围两侧(选取行皮肤软组织扩张术时，同一区域适于同时应用二个100ml扩张器修复病变的患者24例)，两侧各埋植100ml皮肤软组织扩张器一枚；均将其中一侧设为治疗组，另一侧设为对照组(并做标记)，制作HE染色，并随机选取每组各15个视野应用显微标尺测量纤维包膜厚度，了解两组之间的差异性。结果：治疗组纤维包膜厚度532.500±112.033μm，对照组897.000±206.023μm两组比较有统计学差异(P<0.05)。结论：应用几丁糖干预纤维包膜的形成过程，可以使纤维包膜厚度变薄。从而降低其弹性回缩作用。
【关键词】几丁糖；纤维包膜；弹性回缩
【Abstract】Objective: In clinical practice, apply chitosan to intervene the formation of fibrous capsule after expansion. The fiber coating thickness was observed before and after application of chitosan, to explore possible ways that can reduce the flap thickness after expansion, thereby reducing its recoil effect. Methods: Since 2006, applied two dilators for each patient, a total of 24 patients, around each of the patients were on both sides of the lesion (select 24 patients that can apply two 100ml dilator at the same area to repair pathological changes when undergoing skin and soft tissue expansion), both sides implanted one 100ml dilator; the treatment groups will be set to one side, the other side as control group (and marked ), making HE staining, and selected 15 vision randomly from each group ,then use microscopic scale to measure the thickness of fibrous capsule ,to understand the difference between the two groups. Results: The fibrous capsule thickness of the treatment group was 532.500 ± 112.033μm, the control group 897.000 ± 206.023μm, There were significant differences between the two groups (P <0.05). Conclusion: The application of chitosan to intervene the formation of fibrous capsule, makes fiber coating thickness thinner. Thus reducing the recoil effect .
【中图分类号】R622【文献标识码】B【文章编号】1008-6455(2011)06-0161-02
本研究将通过应用几丁糖作为干预药物 ......
(河北大学附属医院 河北 保定 071000)
【摘要】目的：在临床实践中应用几丁糖干预扩张后皮瓣纤维包膜的形成过程，观察应用前后纤维包膜厚度，为临床探索一种能减少扩张后皮瓣纤维薄膜厚度，从而减轻其弹性回缩作用的可行方法。方法：2006年以来，每个患者同时应用二个扩张器修复病变，共对24例患者行皮肤软组织扩张术，每个患者均在病变周围两侧(选取行皮肤软组织扩张术时，同一区域适于同时应用二个100ml扩张器修复病变的患者24例)，两侧各埋植100ml皮肤软组织扩张器一枚；均将其中一侧设为治疗组，另一侧设为对照组(并做标记)，制作HE染色，并随机选取每组各15个视野应用显微标尺测量纤维包膜厚度，了解两组之间的差异性。结果：治疗组纤维包膜厚度532.500±112.033μm，对照组897.000±206.023μm两组比较有统计学差异(P<0.05)。结论：应用几丁糖干预纤维包膜的形成过程，可以使纤维包膜厚度变薄。从而降低其弹性回缩作用。
【关键词】几丁糖；纤维包膜；弹性回缩
【Abstract】Objective: In clinical practice, apply chitosan to intervene the formation of fibrous capsule after expansion. The fiber coating thickness was observed before and after application of chitosan, to explore possible ways that can reduce the flap thickness after expansion, thereby reducing its recoil effect. Methods: Since 2006, applied two dilators for each patient, a total of 24 patients, around each of the patients were on both sides of the lesion (select 24 patients that can apply two 100ml dilator at the same area to repair pathological changes when undergoing skin and soft tissue expansion), both sides implanted one 100ml dilator; the treatment groups will be set to one side, the other side as control group (and marked ), making HE staining, and selected 15 vision randomly from each group ,then use microscopic scale to measure the thickness of fibrous capsule ,to understand the difference between the two groups. Results: The fibrous capsule thickness of the treatment group was 532.500 ± 112.033μm, the control group 897.000 ± 206.023μm, There were significant differences between the two groups (P <0.05). Conclusion: The application of chitosan to intervene the formation of fibrous capsule, makes fiber coating thickness thinner. Thus reducing the recoil effect .
【中图分类号】R622【文献标识码】B【文章编号】1008-6455(2011)06-0161-02
本研究将通过应用几丁糖作为干预药物 ......
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