胎儿纤维连接蛋白在产科中的相关应用(2)
结果提示，阳性者7天内、14天内和37周内分娩的阳性预测值分别为22.7%、41.3%、和65.3%，阴性预测值分别为100%、100%和87.2%。由于FFN预测早产的特异性较低，不主张常规用于无症状的早产低危孕妇。 此外，研究还发现FFN和超声测量宫颈长度相结合，能够使早产的阳性预测率提高为83%～100%。
综上所述，FFN与产科关系极为密切，在孕中期可预测早产，在孕晚期可评价宫颈成熟度和预测分娩时间等。但其仍有很多作用尚未明确，如发现孕早期检测FFN可对妊娠期高血压疾病特别是重度子痫前期具有重要的预测价值,但其机理需进一步研究。
参考文献：
[1] 朱宇，杨艳娟，薛玉珊.宫颈分泌物FFN联合宫颈Bishop评分预测足月妊娠临产时间.中国医师杂志，2008,10(5)：685-686.
[2] Blanch G.The presence of fetal fibronection in the cervicovaginal secretions of women at term:Its role in the assessment of women before labor induction and in the investigation of the physiologic mechanism of labor.Am J Obstet Gynecol,1996,174:262.
[3] Ekman G,Granstroml L,Malmstrom A,et al.Cervical fetal fibronectin correlates to cervical ripening.Acta Obstet Gynecol Scand,1995,74:698-701.
[4] 许倩，许建娟.胎儿纤维连接蛋白对分娩预测的研究.江苏医药.2001,27(11)：834-835.
[5] Lockwood CJ,Moscarelli RD,Wein R,et al.Low concentrations of vaginal fetal fibronectin as a predictor of deliveries occurring after 41 weeks.Am J Obstet Gynecol,1994,171:1-4.
[6] Ahner R,Kiss H,Egarter C,et al.Fetal fibronetin as a marker to predict the onset of term labor and delivery[J].Am J Obstect Gynecol,1995, 172(1pt1):134-137.
[7] 曹泽毅.中华妇产科学(临床版)，北京：人民卫生出版社，2010.119-123.
[8 早产领域的相关问题.现代妇产科进展.2007.16(2):89-92.
[9] Lockwood CJ,Senyei AE,Dische MR,et al.Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery.N Engl J Med,1991,325(10):669-674., 百拇医药(黄晓平 许倩)
综上所述，FFN与产科关系极为密切，在孕中期可预测早产，在孕晚期可评价宫颈成熟度和预测分娩时间等。但其仍有很多作用尚未明确，如发现孕早期检测FFN可对妊娠期高血压疾病特别是重度子痫前期具有重要的预测价值,但其机理需进一步研究。
参考文献：
[1] 朱宇，杨艳娟，薛玉珊.宫颈分泌物FFN联合宫颈Bishop评分预测足月妊娠临产时间.中国医师杂志，2008,10(5)：685-686.
[2] Blanch G.The presence of fetal fibronection in the cervicovaginal secretions of women at term:Its role in the assessment of women before labor induction and in the investigation of the physiologic mechanism of labor.Am J Obstet Gynecol,1996,174:262.
[3] Ekman G,Granstroml L,Malmstrom A,et al.Cervical fetal fibronectin correlates to cervical ripening.Acta Obstet Gynecol Scand,1995,74:698-701.
[4] 许倩，许建娟.胎儿纤维连接蛋白对分娩预测的研究.江苏医药.2001,27(11)：834-835.
[5] Lockwood CJ,Moscarelli RD,Wein R,et al.Low concentrations of vaginal fetal fibronectin as a predictor of deliveries occurring after 41 weeks.Am J Obstet Gynecol,1994,171:1-4.
[6] Ahner R,Kiss H,Egarter C,et al.Fetal fibronetin as a marker to predict the onset of term labor and delivery[J].Am J Obstect Gynecol,1995, 172(1pt1):134-137.
[7] 曹泽毅.中华妇产科学(临床版)，北京：人民卫生出版社，2010.119-123.
[8 早产领域的相关问题.现代妇产科进展.2007.16(2):89-92.
[9] Lockwood CJ,Senyei AE,Dische MR,et al.Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery.N Engl J Med,1991,325(10):669-674., 百拇医药(黄晓平 许倩)