文章编号：1008-6919(2006)08-0051-03

    中图分类号:R965.3

    文献标识码：A

    【摘要】 目的：研究萘普生骨架型缓释颗粒胶囊的制备，减少给药次数，降低不良反应。方法 采用硬脂酸包裹和羟丙甲基纤维素(HPMC)水凝胶缓释技术及UV测定法，研究了萘普生骨架型缓释颗粒胶囊并进行初步稳定性试验。结果 萘普生检测浓度在10.0~50.0μg?ml-1范围内，紫外吸收值(A)与浓度(C)有良好线性关系，r=0.9987；本品缓释效果明显，12h内药物释放曲线符合Higuchi方程，属于扩散释药机制。结论本缓释胶囊处方合理工艺简单，有理想的缓释效果。

    关键词：萘普生；骨架型缓释胶囊，水凝胶缓释技术；释放度；

    The Matrix Sustained-release Granular Capsule of Naproxen Prepared with HPMC

    ABSTRACT OBJECTIVE: To study the preparation of matrix sustained-release granular capsule of naproxen so as to reduce the administration times and adverse effects of the drug. METHODS: The stearic acid coating, hydroxypropyl methylcellulose(HPMC) hydrogel sustained-release and ultraviolet measurement technology were undertaken to study the naproxen matrix sustained-release granular capsule and an initial stability test was also done. RESULTS: The detected range of naproxen concentration lay between 10.0 to 50.0μg, while the absorption value and concentration had a good linear relationship, r=0.9987(the regression coefficient). The product had obvious sustained-release effect, while its release curve within 12 hours complied with the Higuchi equation, which coincided with the diffuse release mechanism. CONCLUSIONS: The sustained release capsule had a reasonable prescription and simple craft. It has ideal sustained release effects. ......