疏血通注射液治疗原发性肾病综合征临床观察(1)
摘 要:目的:通过对疏血通注射液(水蛭和地龙提取物)治疗PNS的临床观察,探讨疏血通注射液治疗PNS的临床疗效,为临床治疗PNS提供客观依据。方法:临床纳入脾肾两虚,水湿壅盛兼有瘀血型PNS患者58例,按就诊顺序随机分为治疗组28例,对照组30例。在基础治疗上,治疗组加用疏血通注射液,对照组加用丹参注射液,以2个月为1个疗程,对两组的疗效进行对比观察。结果:(1)治疗组总有效率为82.14%,对照组总有效率为73.33%。治疗组与对照组的中医证候疗效,经统计学比较有显著性差异。(2)治疗组在减少尿蛋白排出量,提高血浆白蛋白水平,降低血脂,改善肾病综合征高凝状态,降低患者的复发率方面均明显优于对照组,两者相比有显著性差异。结论:疏血通注射液配合基础治疗,能明显改善PNS患者临床症状,减少疾病复发。连续用药对白细胞粒细胞,肝功能无影响,值得临床推广使用。
关键词:原发性肾病综合征;疏血通注射液;丹参注射液; 临床研究
中图分类号:R692 文献标识码:B 文章编号:1673-7717(2010)01-0029-03
, http://www.100md.com
Clinical Study of the Effect of Primary Nephrotic Syndrome Patients Treated by Shuxuetong Injection
SONG Liqun1,ZHANG Yimo2
(1.First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China;
2.Qiqihar Hospital of TCM, Qiqihar 161000, Heilongjiang, China)
Abstract:Objective:To investigate the clinical effects of Shuxuetong injection (extractive of leech and Lumbricus) on primary nephrotic syndrome (PNS) by the clinical observation of Shuxuetong injection on treating PNS, provide objective evidence for the treatment of PNS.Methods: The 58 spleen and kidney asthenia and retention of water with blood stasis patients were divided into treatment group (n=28) and control group (n=30) by the visit order. Besides of the basic treatments, the treatment group were treated with Shuxuetong injection and the control group were treated with Salvia miltiorrhiza injection.After one course of treatment (2 months),the effects of two groups were compared.Results:(1)The total effective rate of treatment group is 82.14%,the control group is 73.33%. There has significant diference of the Traditional Chinese Medicine manifestations between the two groups.(2)The treatment group is better than the control group on reducing the evacuation of proteinuria, promoting plasma-albumin, degrading blood fat, relieving the blood coagulation tendency, reducing relapse rate. There is difference beteen the two groups.Conclusion:Shuxuetong injection coupled with basic treatments can relieve the clinical symptoms obviously, reduce disease relapse. There is no side effects for leucocyte and granulocyte by using medication continually, it is worth for clinical application generally.
, http://www.100md.com
Key words:primary nephritic syndrome(PNS);Shuxuetong injection;Salvia miltiorrhiza injection;clinical study
肾病综合征(Nephrotic Syndrome)是由多种病因和临床疾病引起的一组症候群,常伴有大量蛋白尿(>3.5g/24h)、低白蛋白血症(<30g/L)、水肿及高脂血症。根据病因分为原发性和继发性,PNS的诊断主要依靠排除继发性肾病综合征。对于原发性肾病综合征(PNS)的治疗,西医治疗包括一般治疗及糖皮质激素、细胞毒类药物,疗效尚可,但是这些药物疗程较长,使用后具有一定的副作用并且部分患者对其不敏感或耐药,减量或停药后复发率较高。采用疏血通注射液治疗原发性肾病综合征58例取得了较好疗效,现报道如下。
1 临床资料
1.1诊断标准
, http://www.100md.com
本研究治疗组及对照组均符合1992年《全国原发性肾小球疾病分型与临床诊断专题座谈会纪要》[1]所拟定的标准。
1.1.1 诊断标准 (1)大量蛋白尿(>3.5g/24h);(2)低蛋白血症:血浆白蛋白(<30g/L);(3)明显水肿;(4)高脂血症。其中(1)(2)两项为必备。
1.1.2 入选患者均符合高凝状态的诊断标准 部分凝血活酶时间(APTT)比正常参考值缩短>10s,凝血酶原时间(PT)比正常参考值缩短>3s,纤维蛋白原(Fbg)≥4.0g/L。
1.2一般资料
本研究所纳入的58例患者,来自于2005年4月-2006年3月期间,黑龙江中医药大学附属第一医院肾病科及哈尔滨医科大学附属第二医院肾内科,符合原发性肾病综合征(PNS)诊断标准的住院患者。按就诊顺序随机分为两组:治疗组28例,其中男16例,女12例,年龄(30.00±9.90)岁,病程(8.58±6.14)月;对照组30例,男15例,女15例,年龄(29.93±9.15)岁,病程(7.97±6.37)月。经统计学处理,两组一般资料无显著性差异(P>0.05),具有可比性。, 百拇医药(宋立群 张宜默)
关键词:原发性肾病综合征;疏血通注射液;丹参注射液; 临床研究
中图分类号:R692 文献标识码:B 文章编号:1673-7717(2010)01-0029-03
, http://www.100md.com
Clinical Study of the Effect of Primary Nephrotic Syndrome Patients Treated by Shuxuetong Injection
SONG Liqun1,ZHANG Yimo2
(1.First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China;
2.Qiqihar Hospital of TCM, Qiqihar 161000, Heilongjiang, China)
Abstract:Objective:To investigate the clinical effects of Shuxuetong injection (extractive of leech and Lumbricus) on primary nephrotic syndrome (PNS) by the clinical observation of Shuxuetong injection on treating PNS, provide objective evidence for the treatment of PNS.Methods: The 58 spleen and kidney asthenia and retention of water with blood stasis patients were divided into treatment group (n=28) and control group (n=30) by the visit order. Besides of the basic treatments, the treatment group were treated with Shuxuetong injection and the control group were treated with Salvia miltiorrhiza injection.After one course of treatment (2 months),the effects of two groups were compared.Results:(1)The total effective rate of treatment group is 82.14%,the control group is 73.33%. There has significant diference of the Traditional Chinese Medicine manifestations between the two groups.(2)The treatment group is better than the control group on reducing the evacuation of proteinuria, promoting plasma-albumin, degrading blood fat, relieving the blood coagulation tendency, reducing relapse rate. There is difference beteen the two groups.Conclusion:Shuxuetong injection coupled with basic treatments can relieve the clinical symptoms obviously, reduce disease relapse. There is no side effects for leucocyte and granulocyte by using medication continually, it is worth for clinical application generally.
, http://www.100md.com
Key words:primary nephritic syndrome(PNS);Shuxuetong injection;Salvia miltiorrhiza injection;clinical study
肾病综合征(Nephrotic Syndrome)是由多种病因和临床疾病引起的一组症候群,常伴有大量蛋白尿(>3.5g/24h)、低白蛋白血症(<30g/L)、水肿及高脂血症。根据病因分为原发性和继发性,PNS的诊断主要依靠排除继发性肾病综合征。对于原发性肾病综合征(PNS)的治疗,西医治疗包括一般治疗及糖皮质激素、细胞毒类药物,疗效尚可,但是这些药物疗程较长,使用后具有一定的副作用并且部分患者对其不敏感或耐药,减量或停药后复发率较高。采用疏血通注射液治疗原发性肾病综合征58例取得了较好疗效,现报道如下。
1 临床资料
1.1诊断标准
, http://www.100md.com
本研究治疗组及对照组均符合1992年《全国原发性肾小球疾病分型与临床诊断专题座谈会纪要》[1]所拟定的标准。
1.1.1 诊断标准 (1)大量蛋白尿(>3.5g/24h);(2)低蛋白血症:血浆白蛋白(<30g/L);(3)明显水肿;(4)高脂血症。其中(1)(2)两项为必备。
1.1.2 入选患者均符合高凝状态的诊断标准 部分凝血活酶时间(APTT)比正常参考值缩短>10s,凝血酶原时间(PT)比正常参考值缩短>3s,纤维蛋白原(Fbg)≥4.0g/L。
1.2一般资料
本研究所纳入的58例患者,来自于2005年4月-2006年3月期间,黑龙江中医药大学附属第一医院肾病科及哈尔滨医科大学附属第二医院肾内科,符合原发性肾病综合征(PNS)诊断标准的住院患者。按就诊顺序随机分为两组:治疗组28例,其中男16例,女12例,年龄(30.00±9.90)岁,病程(8.58±6.14)月;对照组30例,男15例,女15例,年龄(29.93±9.15)岁,病程(7.97±6.37)月。经统计学处理,两组一般资料无显著性差异(P>0.05),具有可比性。, 百拇医药(宋立群 张宜默)