莪术油眼用凝胶对HSV-I单纯疱疹病毒性角膜炎的作用(1)
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(1.浙江天瑞药业有限公司 浙江 瑞安 325200；2.温州医学院药学院浙江 温州 325035)
摘 要：目的：考察莪术油眼用凝胶对家兔单纯疱疹病毒性角膜炎的治疗。方法：采用单纯性疱疹病毒HSV-I感染家兔角膜，建立体内病毒感染模型，家兔分别用莪术油眼用凝胶、阿昔洛韦、生理盐水治疗10天，眼角膜每天经荧光素钠染色后，裂隙灯观察药物对家兔病毒性角膜炎模型的治疗作用。结果：与模型组相比，莪术油眼用凝胶和阿昔洛韦组均能有效地治疗单纯疱疹病毒性角膜炎，减轻角膜病变程度，缩短平均治愈时间，其疗效与阿昔洛韦组相似(P>0.05)。结论 莪术油眼用凝胶对单纯疱疹病毒性角膜炎有明显的治疗作用。
关键词：莪术油眼用凝胶；单纯疱疹病毒；病毒性角膜炎
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0522-03
Effect of Zedoary oil Ophthalmic Gel on HSV-I herpes Simplex Keratitis
CUI You1，LIU Min2, JIANG Cheng-Xi2
(1.Zhejiang Tianrui Pharmaceutical Co.,Ltd.,Ruian 325200,Zhejiang,China；2.Wenzhou Medical College,Wenzhou 325035,Zhejiang,China)
Abstract:objective:To observe the therapeutic efficacy ofzedoary oil Ophthalmic Gel on herpes simplex keratitis.Methods:By herpes simplex keratitis infection was established to observe the in vivio anti-viral effects ofzedoary oil Ophthalmic Gel,ACV and normal saline for 10 days respectively,and the effects were studied through the observation of the rabbit comeas by slit-lamp exam ination after dyeing flouresce in-natrium.Results:Compared with model group ,both zedoary oil Ophthalmic Gel and ACV significantly reduced severity of HSV-I dendritic Keratitis,shortened healing time of HSK.There was no statistical significance between zedoary oil Ophthalmic Gel and ACV (P<0.05). Conclusion:Zedoary oil Ophthalmic Gel has evident effects on HSK,it can be developed as a new drug for HSK.
Key words:Zedoary oil Ophthalmic Gel;herpes simplex virus;viral keratitis
病毒性角膜炎是重要的致盲性眼病之一 ......
(1.浙江天瑞药业有限公司 浙江 瑞安 325200；2.温州医学院药学院浙江 温州 325035)
摘 要：目的：考察莪术油眼用凝胶对家兔单纯疱疹病毒性角膜炎的治疗。方法：采用单纯性疱疹病毒HSV-I感染家兔角膜，建立体内病毒感染模型，家兔分别用莪术油眼用凝胶、阿昔洛韦、生理盐水治疗10天，眼角膜每天经荧光素钠染色后，裂隙灯观察药物对家兔病毒性角膜炎模型的治疗作用。结果：与模型组相比，莪术油眼用凝胶和阿昔洛韦组均能有效地治疗单纯疱疹病毒性角膜炎，减轻角膜病变程度，缩短平均治愈时间，其疗效与阿昔洛韦组相似(P>0.05)。结论 莪术油眼用凝胶对单纯疱疹病毒性角膜炎有明显的治疗作用。
关键词：莪术油眼用凝胶；单纯疱疹病毒；病毒性角膜炎
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0522-03
Effect of Zedoary oil Ophthalmic Gel on HSV-I herpes Simplex Keratitis
CUI You1，LIU Min2, JIANG Cheng-Xi2
(1.Zhejiang Tianrui Pharmaceutical Co.,Ltd.,Ruian 325200,Zhejiang,China；2.Wenzhou Medical College,Wenzhou 325035,Zhejiang,China)
Abstract:objective:To observe the therapeutic efficacy ofzedoary oil Ophthalmic Gel on herpes simplex keratitis.Methods:By herpes simplex keratitis infection was established to observe the in vivio anti-viral effects ofzedoary oil Ophthalmic Gel,ACV and normal saline for 10 days respectively,and the effects were studied through the observation of the rabbit comeas by slit-lamp exam ination after dyeing flouresce in-natrium.Results:Compared with model group ,both zedoary oil Ophthalmic Gel and ACV significantly reduced severity of HSV-I dendritic Keratitis,shortened healing time of HSK.There was no statistical significance between zedoary oil Ophthalmic Gel and ACV (P<0.05). Conclusion:Zedoary oil Ophthalmic Gel has evident effects on HSK,it can be developed as a new drug for HSK.
Key words:Zedoary oil Ophthalmic Gel;herpes simplex virus;viral keratitis
病毒性角膜炎是重要的致盲性眼病之一 ......
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