两种子宫内膜异位症大鼠模型的血液流变学及单胺类神经递质比较研究(1)
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摘 要：目的：通过对病证结合和单纯疾病两种子宫内膜异位症(EMT)动物模型血液流变学和单胺类神经递质进行比较研究，探索微观量化指标在模型建立中的意义，为中医药治疗子宫内膜异位症提供可靠的研究载体。方法：采用手术移植的方法建立子宫内膜异位症模型，然后在疾病模型的基础上给予多因素刺激建立病证结合子宫内膜异位症模型。测定两种模型及空白对照组的血液流变学及单胺类神经递质并进行比较。结果：(1)与空白对照组相比，病证结合组的全血黏度低切，血沉，血沉方程K值均明显增高，二者比较有统计学差异(P<0.05)。(2)与单纯疾病模型组相比，病证结合模型组全血黏度高切、中切，全血还原黏度低切、中切、高切，红细胞刚性指数，纤维蛋白原均明显增高，二者比较有统计学差异(P<0.05)。(3)与单纯疾病模型组相比，病证结合模型组血清中DA、NE含量明显升高，二者比较有显著性差异(P<0.05、P<0.01)。结论：血液流变学及单胺类神经递质可以作为验证气滞血瘀子宫内膜异位症模型的量化指标。
关键词：子宫内膜异位症；动物模型；实验研究
中图分类号：R285.5 文献标识码：A 文章编号：1673-7717(2012)01-0179-03
Comparative Research on Hemorheology And Monoamine
Neurotransmitter in Two Types of Endometriosis Rats Model
MA Xiaonan,LIU Dantong,YAN Juntang,XU Hong,WANG Qingguo
(Beijing University of Chinese Medicine，Beijing 100029，China)
Abstract:Objective：Through comparative study of hemorheology and monoamine neurotransmitter to disease and syndrome animal models and simple disease animal models of EMT to explore the micro-quantitative indicators of the significance of the model for the medical treatment of endometriosis offers reliable research carrier. Methods：First, use the transplant surgery methods to establish endometriosis model, and then based on the model of the disease to give multiple factors to establish disease and syndrome stimulate endometriosis model. Determination hemorheology and monoamine neurotransmitters of the two models and the control group and compared. Results：(1)Compared with the control group, in disease and syndrome group,low shear whole blood viscosity, ESR, erythrocyte sedimentation rate and K values were significantly higher, there is statistical difference between the two groups(P<0.05). (2) Compared with simple models of disease,in disease and syndrome model group,high shear whole blood viscosity,whole blood reduced viscosity at low shear, the shear, high shear, erythrocyte rigidity index, and fibrinogen were significantly higher, there were significant differences (P<0.05). (3) Compared with simple models of disease,in disease and syndrome model group, the serum DA, NE levels increased significantly, both were significantly different (P<0 ......
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