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从脾虚痰浊论治糖调节受损患者糖、脂代谢紊乱及对血清脂联素的影响(1)
http://www.100md.com 2012年4月1日 毛丹丹,林士毅,苏孝共
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     摘 要:目的:探讨从脾虚痰浊论治糖调节受损患者的糖、脂代谢紊乱及对血清脂联素的影响并分析其机制。 方法:将50例糖调节受损患者随机分成两组。中药组采用健脾化浊方加减治疗,西药组采用吡咯列酮治疗。疗程均为12周,观察两组治疗前后的体质指数(BMI),血清脂联素、空腹血糖(FBG)、餐后2h血糖(2hBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并于治疗前与健康对照组比较。结果:治疗前,两治疗组较对照组BMI、FBG、2hBG、TG、TC、LDL-C高,血清脂联素、HDL-C低(P<0.05或P<0.01);中药组与西药组治疗后BMI、FBG、2hBG、TG、TC、LDL-C降低,血清脂联素、HDL-C升高(P<0.05或P<0.01);中、西药两组治疗前后各指标比较,无明显差异(P>0.05)。结论:糖调节受损阶段中医病机为脾气不足,痰浊壅盛,此期采用健脾化浊方健脾益气,升清化浊,可改善糖调节受损患者糖脂代谢紊乱,其机制应与升高血清脂联素水平,改善胰岛素抵抗程度有关。

    关键词:糖调节受损;脂代谢紊乱;血清脂联素;脾虚;痰浊

    中图分类号:R587.1

    文献标识码:A

    文章编号:1673-7717(2012)04-0734-03

    Treatment of Dysmetabolic Syndrome of Glucose And Fat in IGR Patients And the Effect on Serum Adiponectin Based on the Mechanism of Turbid Phlegm Due to Spleen Deficiency

    MAO Dan-dan,LIN Shi-yi,SU Xiao-gong

    (The Second Affliated Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang, China)

    Abstract:Objective: To explore the treatment of dysmetabolic syndrome of glucose and fat in IGR patients and the effect on serum adiponectin based on the mechanism of turbid phlegm due to spleen deficiency. Methods:Randomly divide 50 cases of IGR patients into 2 treatment groups: Chinese medicine group with Jianpi Huazhuo prescription while western medicine group with pioglitazone. All treatments were given for 12 weeks. The levels of BMI,FBG,2hBG,TG,TC,HDL-C,LDL-C,serum adiponectin of 2 groups were observed and compared before and after treatments. Results: Before treatment, the 2 treatment groups had higher levels on BMI,FBG,2hBG,TG,TC and LDL-C, and lower levels on serum adiponectin and HDL-C, which had statistical differences with control group, respectively (P<0.05 or P<0.01). The levels of 2 treatment groups decreased on BMI、FBG、2hBG、TG、TC、LDL-C, and increased on serum adiponectin and HDL-C after treatment, which had statistical differences with the levels before treatment, respectively (P<0.05 or P<0.01). There were no statistical difference between the 2 treatment groups either before or after treatment ......

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