健脾泻肺法治疗非糜烂性胃食管反流病的临床观察(1)
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摘 要：目的：观察健脾泻肺法治疗非糜烂性胃食管反流病的临床疗效。方法：将NERD患者，辨证属中虚气逆证共120例随机分为治疗者(60例)和对照组(60例)，对照组采用雷贝拉唑、莫沙比利治疗；治疗组在此基础上，加用健脾泻肺法中药汤剂，两组疗程均为8周。观察治疗前后临床症状积分变化，并随访半年。结果：治疗后，两组症状积分较治疗前均有显著下降(P<0.01)，临床总有效率分别为93.33%、91.67%，差异无统计学意义(P>0.05)，但停药半年后复发情况比较，治疗组复发率为7.55%，明显低于对照组41.51%(P<0.01)。结论：健脾泻肺法治疗非糜烂性胃食管反流病疗效确切，与西药合用远期疗效更佳。
关键词：非糜烂性胃食管反流病；中西医结合疗法；健脾泻肺法;雷贝拉唑
中图分类号：R573.3
文献标识码：B
文章编号：1673-7717(2012)04-0842-03
Clinical Observation on Method of Invigorating Spleen And Weakening
Lung to Treat Non-Erosive Reflux Disease
ZHOU Shui-ying，LU Wei-hong，CHENG Sheng-ping
(Wenling Hospital of Traditional Chinese Medicine，Wenling 317500，Zhejiang，China)
Abstract:Objective：To observe the clinical effect of non-erosive reflux disease(NERD)by using the invigorating spleen and weakening lung treatment of TCM.Methods：120 patients with NERD of syndrome of middle deficiency and Qi reversal were randomly divided into two groups：treatment group(60 cases)and control group(60 cases).Patients in control group would be treated by rabeprazole and mosapride；patients in treatment group would be treated by rabeprazole，mosapride and the invigorating spleen and weakening lung treatment of TCM .The treatment course was 8 weeks. Symptom scores of NERD were measured before and after treatments，and followed for half a year.Results：After treatment，compared with pretreatment，the symptom scores decreased significantly in both groups(P<0.01)；the total clinical effective rate of the treatment group was 93.33%，not significantly different from that of the control group 91.67%(P >0.05)，but after half a year，the recurrence rate of the treatment group was 7.55%，much lower than that of the control group 41.51%(P<0.01).Conclusion：The invigorating spleen and weakening lung treatment of TCM was effective on NERD，and the long term effect could be better if integrated with western medicine.
Key words:non-erosive reflux disease；therapy of combine TCM and western medicine；invigorating spleen and weakening lung；rabeprazole
胃食管反流病(GERD)是由于胃、十二指肠内容物反流至食管,而导致的一系列慢性症状和食管黏膜损害 ,还可引起咽喉、气道等食管以外的组织病变。GERD包括反流性食管炎(RE)、非糜烂性胃食管反流病(NERD)及Barrett食管。NERD 是指具有典型的反流症状,但内镜检查食管黏膜正常者,亦称内镜阴性反流病[1]。在GERD中NERD 的比例高达60%～70%[2]。NERD严重影响人们的身体健康和生活质量 ......
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