β-淀粉蛋白的研究进展(2)
[5] Huang HM，Ou HC，Hsieh SJ， et al. Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons[J].Life Sci，2000，66(19):1879.
[6] Woltjer RL，Maezawa I，Ou JJ，et al.AGE precursor alters intracellu-lar amyloid-APP carboxy-terminal fragment aggregation and cytotox-ocity[J].Journal of Alzheimer Disease，2003，5(6):467.
[7] Takeuchi M，Bucala R，Suzuki T，et al.intraneuronal advanced glyca-tion endproducts for cultures cortical neurons[J]. JNeuropathol Exp Neurol，2000，59(12):1094.
[8] Luo Y，Bolon B，Kahn S，et al.Mice deficient in BACE1，the Alzhei-mer’s disease patients [J].Nat Neyrosci，2001，4:231.
[9] Wyss-Coray T，Loike JD，Brionne TC，et al.Serum insulin-like grow-th factor Ⅰ regulates brain amyloid-β in vivo and in situ [J].Nat Med，2003，9(4):453.
[10] Chacon MA，Barria MI，Sato C，et al.β-sheet breaker peptide pre-vents Aβ-induced spatial memory impaiments with partial reduc-tion of amyloid deposits [J].Mol Psychiatry，2004，(4):20.
[11] Annaert W，De Strooper B.A cell biological perspective on Alzheimer’s disease [J].Annu Rev Cell Der Biol，2002，18:25.
收稿日期：2008-04-29 修回日期：2008-05-04, 百拇医药(张宁宁 丁 也 桑 亮)
[6] Woltjer RL，Maezawa I，Ou JJ，et al.AGE precursor alters intracellu-lar amyloid-APP carboxy-terminal fragment aggregation and cytotox-ocity[J].Journal of Alzheimer Disease，2003，5(6):467.
[7] Takeuchi M，Bucala R，Suzuki T，et al.intraneuronal advanced glyca-tion endproducts for cultures cortical neurons[J]. JNeuropathol Exp Neurol，2000，59(12):1094.
[8] Luo Y，Bolon B，Kahn S，et al.Mice deficient in BACE1，the Alzhei-mer’s disease patients [J].Nat Neyrosci，2001，4:231.
[9] Wyss-Coray T，Loike JD，Brionne TC，et al.Serum insulin-like grow-th factor Ⅰ regulates brain amyloid-β in vivo and in situ [J].Nat Med，2003，9(4):453.
[10] Chacon MA，Barria MI，Sato C，et al.β-sheet breaker peptide pre-vents Aβ-induced spatial memory impaiments with partial reduc-tion of amyloid deposits [J].Mol Psychiatry，2004，(4):20.
[11] Annaert W，De Strooper B.A cell biological perspective on Alzheimer’s disease [J].Annu Rev Cell Der Biol，2002，18:25.
收稿日期：2008-04-29 修回日期：2008-05-04, 百拇医药(张宁宁 丁 也 桑 亮)