整合素与脓毒症心肌损伤的关系(2)
综上所述，整合素家族在人体组织中分布广泛，介导的信号转导通路在调节细胞功能中具有 重要作用，在很多方面影响着人类生命的特性。研究显示整合素与脓毒症心肌损害有密切关 系，因此可能为临床干预或治疗脓毒症心肌抑制提供新的思路。相信随着研究的深入，人们 会发现整合素更多的功能，在疾病的治疗中取得新的突破。
参考文献
[1]张召才，严静，蔡国龙，等.整合素基因在脓毒症大鼠心脏中的表达变化[J ].中华医学杂志，2007，87(7)：497-500.
[2]Humphries JD, Byron A, Bass MD, et al. Proteomic analysis of integrin_asso ciated complexes identifies RCC2 as a dual regulator of Racl and Arf6[J].Scien ce signaling，2009，2(87)：ra51.
, 百拇医药
[3]Shattil SJ, Kim C, Ginsberg ME. The final steps of integrin activation: th e end game[J]. Nature reviews，2010，11(4)：288-300.
[4]Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance[J]. Jou rnal of cell science，2006，119(19)：3901-3903.
[5]Staunton DE, Lupher ML, Liddington R, et al. Targeting integrin structureand function in disease[J]. Advances in immunology，2006，91：111-157.
[6]Liu SH CD, Ginsberg MH. Integrin cytop las_mic domain_binding proteins[1] . Cell Sci，2000，113：3563-3571.
, 百拇医药
[7]LalH G1eaR, Foster DM, Lu G， et al. Integrins： novel therapeutic targetsfor cardiovascular diseases[J]. Cardiovasc Hematol Agents Med Chem，2007，5(2) ：109-132.
[8]Sheppard AM, Onken MD, Rosen GD, et al .Expanding roles for alpha 4 integri n and its ligands in development[J]. Cell adhesion and communication，1994，2 ：27-43.
[9]Imanaka_Yoshida K, Enomoto_Iwamoto M, Yoshida T, et al. Integrin alpha6be tal and laminin can serve as components of attachment complex mediating contract ion force transmission from cardiomyocytes to extracellular matrix[J]. Cell mo tility and the cytoskeleton，1999，42(1)：1-11.
, 百拇医药
[10]Shai SY, Harpf AE, Babbitt CJ, et al. Cardiac myocyte_specific excision ofthe betal integrin gene results in myocardial fibrosis and cardiac failure[J] . Circulation research，2002，90(4)：458-464.
[11]Wang YG, Samarel AM, Lipsius SL. Laminin acts via beta I integrin signalli ng to alter cholinergic regulation of L_type Ca2+ current in cat atrial m yocytes[J].The J ournal of physiology，2000，526(1)：57-68.
[12]Martinez_Lemus LA, Sun Z, Trache A, et al. Integrins and regulation of th e microcirculation: from arterioles to molecular studies using atomic force micr oscopy[J]. Microcirculation，2005，12(1)：99-112.
, 百拇医药
[13]Alberti C, Brun_Buisson C, Burchardi H, et al. Epidemiology of sepsis andinfection in ICU patients from an international multicentre cohort study[J].Intensive care medicine，2002，28(2)：108-121.
[14]Zarbock A, Ley K. Mechanisms and consequences of neutrophil interaction w ith the endothelium[J]. The American journal of pathology，2008，172(1)：1-7 .
[15]Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocy te adhesion and migration[J]. Immunological reviews，2007，218：126-134.
, http://www.100md.com
[16]Otis M, Campbell S, Payet MD, et al. The growth_promoting effects of angi otensin Ⅱ in adrenal glomerulosa cells: an interactive tale[J]. Molecular andcellular endocrinology，2007，273(1-2)：1-5.
[17]Bloch W, Fan Y, Han J, et al. Disruption of cytoskeletal integrity impairsGi_mediated signaling due to displacement of Gi proteins[J]. The Journal of c ell biology，2001，154(4)：753-761., http://www.100md.com(陆云燕 严静)
参考文献
[1]张召才，严静，蔡国龙，等.整合素基因在脓毒症大鼠心脏中的表达变化[J ].中华医学杂志，2007，87(7)：497-500.
[2]Humphries JD, Byron A, Bass MD, et al. Proteomic analysis of integrin_asso ciated complexes identifies RCC2 as a dual regulator of Racl and Arf6[J].Scien ce signaling，2009，2(87)：ra51.
, 百拇医药
[3]Shattil SJ, Kim C, Ginsberg ME. The final steps of integrin activation: th e end game[J]. Nature reviews，2010，11(4)：288-300.
[4]Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance[J]. Jou rnal of cell science，2006，119(19)：3901-3903.
[5]Staunton DE, Lupher ML, Liddington R, et al. Targeting integrin structureand function in disease[J]. Advances in immunology，2006，91：111-157.
[6]Liu SH CD, Ginsberg MH. Integrin cytop las_mic domain_binding proteins[1] . Cell Sci，2000，113：3563-3571.
, 百拇医药
[7]LalH G1eaR, Foster DM, Lu G， et al. Integrins： novel therapeutic targetsfor cardiovascular diseases[J]. Cardiovasc Hematol Agents Med Chem，2007，5(2) ：109-132.
[8]Sheppard AM, Onken MD, Rosen GD, et al .Expanding roles for alpha 4 integri n and its ligands in development[J]. Cell adhesion and communication，1994，2 ：27-43.
[9]Imanaka_Yoshida K, Enomoto_Iwamoto M, Yoshida T, et al. Integrin alpha6be tal and laminin can serve as components of attachment complex mediating contract ion force transmission from cardiomyocytes to extracellular matrix[J]. Cell mo tility and the cytoskeleton，1999，42(1)：1-11.
, 百拇医药
[10]Shai SY, Harpf AE, Babbitt CJ, et al. Cardiac myocyte_specific excision ofthe betal integrin gene results in myocardial fibrosis and cardiac failure[J] . Circulation research，2002，90(4)：458-464.
[11]Wang YG, Samarel AM, Lipsius SL. Laminin acts via beta I integrin signalli ng to alter cholinergic regulation of L_type Ca2+ current in cat atrial m yocytes[J].The J ournal of physiology，2000，526(1)：57-68.
[12]Martinez_Lemus LA, Sun Z, Trache A, et al. Integrins and regulation of th e microcirculation: from arterioles to molecular studies using atomic force micr oscopy[J]. Microcirculation，2005，12(1)：99-112.
, 百拇医药
[13]Alberti C, Brun_Buisson C, Burchardi H, et al. Epidemiology of sepsis andinfection in ICU patients from an international multicentre cohort study[J].Intensive care medicine，2002，28(2)：108-121.
[14]Zarbock A, Ley K. Mechanisms and consequences of neutrophil interaction w ith the endothelium[J]. The American journal of pathology，2008，172(1)：1-7 .
[15]Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocy te adhesion and migration[J]. Immunological reviews，2007，218：126-134.
, http://www.100md.com
[16]Otis M, Campbell S, Payet MD, et al. The growth_promoting effects of angi otensin Ⅱ in adrenal glomerulosa cells: an interactive tale[J]. Molecular andcellular endocrinology，2007，273(1-2)：1-5.
[17]Bloch W, Fan Y, Han J, et al. Disruption of cytoskeletal integrity impairsGi_mediated signaling due to displacement of Gi proteins[J]. The Journal of c ell biology，2001，154(4)：753-761., http://www.100md.com(陆云燕 严静)