【Abstract】ObjectiveTo explore the impact of lung-protective mechanical ventilation (low tidal volume and optimal positive end-expiratory pressure (PEEP) on cerebral perfusion pressure (CPP) and cerebral oxygen metabolism. MethodsForty patients with severe cerebral injury along with respiratory failure were randomly assigned into two groups： lung-protective ventilation group A and conventional ventilation group B. Group A was planned to prescribe tidal volume 6～8 mL/kg ......