血清β淀粉样肽40与2型糖尿病下肢大血管病变的相关性研究(2)
綜上所述，β淀粉样肽可以通过调节胰岛素抵抗、氧化应激、炎症反应、钙磷代谢等作用，加强多个致动脉粥样硬化的危险因子，深入研究其作用机制，可为防治下肢血管病变提供新的思路。
参考文献
[1].Nacci C， Tarquinio M， Montagnani M. Molecular and clinical aspects of endothelial dysfunction in diabetes[J]. Intern Emerg Med， 2009， 4(2)： 107-116.
[2].Potenza MA， Gagliardi S， Nacci C， et al. Endothelial dysfunction in diabetes： from mechanisms to therapeutic targets[J]. Curr Med Chem， 2009， 16(1)： 94-112.
[3].Margo P Cohen， Clyde W Shearman. Reducion of Aβ42 in brains of transgeninc APPSWE
MICE by 2-3-chlorophenylaminophenylacetate[J].Clinical and Experimental Pharmacology and Physiology， 2009， 36(11)： 1099-1103.
[4].Phiel CJ， Wilson CA， Lee VM， et al. GSK-3α regulates production of Alzheimer’s disease
amyloid-β peptides[J]. Nature， 2003， 423(22)： 435-439.
[5].BENeedham，MEWlodek，GDCiceotosto，et al.Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth[J].J.Pathol， 2008， 215(2)： 155-163.
[6].Y H Lee， W G Tharp， R L Maple， et a1. Amyloid precursor protein expression is upregulated in adipocytes in obesity[J]. Obesity(Silver Spring)， 2008， 16(7)： 1493-1500. (廖新华 苟永慧)
参考文献
[1].Nacci C， Tarquinio M， Montagnani M. Molecular and clinical aspects of endothelial dysfunction in diabetes[J]. Intern Emerg Med， 2009， 4(2)： 107-116.
[2].Potenza MA， Gagliardi S， Nacci C， et al. Endothelial dysfunction in diabetes： from mechanisms to therapeutic targets[J]. Curr Med Chem， 2009， 16(1)： 94-112.
[3].Margo P Cohen， Clyde W Shearman. Reducion of Aβ42 in brains of transgeninc APPSWE
MICE by 2-3-chlorophenylaminophenylacetate[J].Clinical and Experimental Pharmacology and Physiology， 2009， 36(11)： 1099-1103.
[4].Phiel CJ， Wilson CA， Lee VM， et al. GSK-3α regulates production of Alzheimer’s disease
amyloid-β peptides[J]. Nature， 2003， 423(22)： 435-439.
[5].BENeedham，MEWlodek，GDCiceotosto，et al.Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth[J].J.Pathol， 2008， 215(2)： 155-163.
[6].Y H Lee， W G Tharp， R L Maple， et a1. Amyloid precursor protein expression is upregulated in adipocytes in obesity[J]. Obesity(Silver Spring)， 2008， 16(7)： 1493-1500. (廖新华 苟永慧)