老年冠心病患者血清胆红素和超敏C反应蛋白水平的变化分析(1)
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[摘要] 目的:分析血清胆红素和超敏C反应蛋白(hs-CRP)水平与冠心病的关系及规律用药的重要性。方法: 对150例经冠状动脉造影明确诊断为冠心病的患者(治疗组)和150例无冠心病的老年人(对照组)测定血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IDBIL)水平以及hs-CRP水平；治疗组患者规律用药12个月后复查上述指标。结果: 治疗组血清TBIL和IDBIL水平明显低于对照组(P<0.05),而hs-CRP水平明显高于对照组(P<0.05)；12个月后，治疗组血清TBIL和IDBIL水平升高，hs-CRP水平下降，与自身比较有显著性差异(P<0.05)。结论: 血清胆红素水平升高可能在冠心病发病中具有一定的保护作用；血清胆红素和hs-CRP水平均可作为病情监测的指标；规律用药对老年冠心病患者具有重要意义。
[关键词] 血清胆红素； 超敏C反应蛋白； 冠心病
[中图分类号] R541.4 [文献标识码] A [文章编号] 1671-7562(2011)01-0032-04
doi:10.3969/j.issn.1671-7562.2011.01.009
[收稿日期] 2010-09-26 [修回日期] 2010-10-22
[作者简介] 王瑞涛(1971-)，男，黑龙江哈尔滨人，副主任医师，医学硕士。E-mail： ruitao06@yahoo.com.cn
[通信作者] 李颖 E-mail： liying55@yahoo.com.cn
Analysis of serum bilirubin and high-sensitivity C-reactive protein
in elderly patients with coronary artery disease
WANG Rui-tao， MENG Song-yan， YANG Yi， LI Ying
(Department of Geriatrics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)
[Abstract] Objective: To evaluate clinical value of the serum bilirubin and serum high-sensitivity C-reactive protein(hs-CRP) in patients with coronary artery disease and stress the importance of maintenance of regular medication. Methods: 150 cases with coronary artery disease(diagnosed by angiography) were collected and 150 cases without coronary artery disease served as controls. The levels of serum bilirubin and Hs-CRP were measured. The patients with coronary artery disease received regular medication for 12 months and the levels of serum bilirubin and Hs-CRP were re-tested. Results: In the treatment group, TBIL and IDBIL levels decreased(P<0.05), hs-CRP level significantly elevated compared with those in control group(P<0.05). Twelve months later, TBIL and IDBIL levels of the patients with coronary artery disease increased(P<0.05), hs-CRP level was decreased significantly compared with themselves(P<0.05). Conclusion: The elevated TBIL and IDBIL play a protective role in the mechanism of coronary artery disease. Serum bilirubin and Hs-CRP level in patients with coronary artery disease may serve as therapeutic indicators ......
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