液基细胞学联合HPV基因分型检测在宫颈癌前病变筛查中的应用(1)
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[摘要] 目的:探讨液基细胞学检查(TCT)联合人乳头瘤病毒(HPV)基因分型检测在宫颈癌前病变筛查中的作用。方法：对我院2009年6月至2009年12月门诊TCT为非典型鳞状上皮细胞(ASCUS)及以上的患者行HPV基因分型检测。结果：(1) ASCUS及以上患者同时合并HPV阳性者共116例，其中ASCUS、LSIL、HSIL、SCC的例数(阳性率)依次为69(60%)、36(31%)、6(5%)、5(4%)；116例患者中HPV高危型39例，AUSCS、LISL、HISL、SCC HPV高危型例数(阳性率)依次为16(23%)、14(39%)、4(67%)、5(100%)，显示SCC与HPV高危型感染密切相关。(2) HPV高危型39例，平均年龄42.1岁；HPV低危型77例，平均年龄33.5岁；两者比较有显著性差异。结论：TCT与HPV基因分型检测是筛查宫颈病变的有效方法，对患者的随访具有重要意义。
[关键词] 液基细胞学； 人乳头瘤病毒； 宫颈病变； 诊断
[中图分类号] R711.32 [文献标识码] A [文章编号] 1671-7562(2011)01-0045-03
doi:10.3969/j.issn.1671-7562.2011.01.013
[收稿日期] 2010-09-27 [修回日期] 2010-12-05
[作者简介] 姜清明(1971-),男,江西南昌人，主管检验师。
Application of thinprep cytologic test combined HPV-DNA checking
in cervical screening of precancerous lesions
JIANG Qing-ming
(Department of Laboratory, the Second People's Hospital of Shaoguan City, Shaoguan 512028， China )
[Abstract] Objective: To discuss the application of thinprep Cytologic Test combined HPV-DNA checking in cervical screening for precancerous lesions. Methods: HPV-DNA checking was performed in patients in our hospital who underwent TCT and showed positive(ASCUS and above)during June 2009 through December 2009.Results: (1) The number of TCT positive combined HPV infection was 116, including ASCUS 69(60%), LSIL 36(31%), HSIL 6(5%), SCC 5(4%). 39 out of 116 cases were the highly risky type of HPV, with the positive rates 16(23%), 14(39%), 4(67%) and 5(100%) respectively in AUSCS, LISL, HISL and SCC, indicating SCC closely correlated with high risk type of HPV infection. (2) The average age of the 39 high risk type of HPV infection cases was 42.1, while it was 33.5 in the 77 low risk type of HPV infection cases, which showed a significant differences. Conclusion: TCT and HPV-DNA checking in cervical screening for precancerous lesions is an effective method, which has a great significance to the following up patients.
[Key words] thinprep cytologic test； human papillomavirus； cervical lesions； diagnosis
宫颈癌是最常见的妇科恶性肿瘤之一，全世界范围内其发病率和死亡率仅次于乳腺癌[1]。人乳头瘤病毒(human papillomavirus，HPV)的持续感染是癌前病变及宫颈癌发病的重要致病因子[2] ......
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