PKC及NSE在SAH后迟发性脑血管痉挛中的作用(2)
 |
| 第1页 |
参见附件(2023KB，3页)。
研究结果进一步提示，SAH患者血浆PKC与神经细胞损伤定量生化标志物-NSE的改变明显相关。NSE作为神经元损害的定量生化标志物已为多数研究者认定，作为评价脑损伤的生化标志物，在昏迷、脑外伤、癫痫、脑血管病等病症中显示出重要的临床价值【sup】[13]【/sup】。研究显示SAH患者血浆PKC与NSE有明显相似的变化规律，并且与脑血流速度密切相关，说明在PKC升高和脑血管痉挛的过程中，伴随神经元损伤的增加，显示出PKC在SAH病理演变过程中重要的临床价值，提示PKC可能作为SAH急性期脑损害的生化指标应用于临床。
参考文献：
[1] Dietrich HH,Dacey RG.Molicular keys to the problems of cerebral vasospasm[J].Neurosurgery,2000,46:517-530.
[2] Macdonald RL,Weir BKA.A review of hemoglobin and the pathogenesis of cerebral vasospasm[J].Stroke,1991,22:971-982.
[3] 梁敏，王守田.调节神经元凋亡信号转导途径的关键酶：死亡相关蛋白激酶[J].中国危重病急救医学杂志，2005，17(7)：318-319.
[4] Matsui T,Takuwa Y,Joshita H,et al.Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm[J].J Cereb Blood Flow Metab,1991,11:143-149.
[5] Somlyo AP,Somlyo AV.Signal transduction by G proteins,Rho kinase and protein phosphatase to smooth muscle and non-muscle myosin Ⅱ[J].J Physiol,2000,522:177-185.
[6] Sato M,Tani E,Fujikawa H,et al.Involvement of Rho-kinase mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm[J].Circ Res,2000,87:195-200.
[7] Wickman G,Lan C,Vollrath B.Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin:Relevance to subarachnoid hemorrhage and vasospasm[J].Circ Res,2003,92(7):809-816.
[8] Onoue H,Kaito N,Akiyama M,et al.Altered reactivity of human cerebral arteries after subarachnoid hemorrhage[J] ......
您现在查看是摘要介绍页，详见PDF附件(2023KB，3页)。