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    Effects of Metoprolol and Bisoprolol on Heart Rate Control and Vascular Endothelial Function in Patients with Hypertension

    Hu Xiurong,Chen Jie,He Maojiang

    Leshan Geriatric Disease Specialized Hospital,Leshan 614000,Sichuan,China

    Abstract:Objective To investigate the effects of metoprolol and bisoprolol on heart rate control and vascular endothelial function in patients with hypertension.Methods Two hundreds and eighty patients with hypertension in our hospital from February 2016 to February 2017 were selected,and divided into three groups by basic heart rate (HR):group A (n=90,HR with 70/min to 79/min),group B (n=116,HR with 80/min to 89/min),and group C (n=74,HR with more than 90/min).Then patients in group A,group B,and group C were randomly divided into metoprolol subgroup and bisoprolol subgroup.The patients in metoprolol subgroup and bisoprolol subgroup were treated with metoprolol and bisoprolol,respectively.The heart rate and vascular endothelial function were observed.Results Before treatment,there was no significant difference in heart rate,endothelin level and nitric oxide concentration between metoprolol subgroup and bisoprolol subgroup in group A,group B and group C (P>0.05).After treatment,the heart rate in group A,group B and group C decreased significantly,endothelin level decreased significantly,and nitric oxide concentration increased significantly in metoprolol subgroup and bisoprolol subgroup in group A,group B and group C (P1 资料与方法 ......