doi：10.12102/j.issn.1672-1349.2025.14.007

    EfectsofPanaxNotoginsengSaponinsonMyocardiallschemia-reperfusionInjuryinRatsandtheMechanismofAnti-pyroptosis ZHAOWeikun1，UTongtong'，UXiangwe，QNYang1，LUFengxia1，Yuting2，HUANGYul，OQ，UHuaxin，Ue

    1.TheFirst AfaesiafuindaUveitunag，ina;uiicavsit99 Guangxi， China

    Corresponding AuthorQINYang，E-mail：1258778506@qq.com;LYU Xiangwei，E-mail：lvxiangwei910 @ 163.com

    AbstractObjective：ToobservetheefectofPanaxnotoginsengsaponins(PNS)onmyocardialischemia-repefusion(I)injuryand exploreitsmechanismrelatedtotheregulationofcardiomyocytepyroptosis.Methods：EighteenadultmaleSDratsweredividedintosham group，IR groupandPSgroupbyrandomnumbertablemethod，with6ratsineach group.Themodelwaspreparedbyligatigtheleft anteriordescendingcoronaryarteryAD)ofratswithischemiafor30minutesandreperfusionfor2hours.Theatsinthesamgroupand the IR groupwere intraperitoneally injectedwith normal saline( 10mL/kg) ，while those in the PNS groupwere intraperitoneally injected with (20 PNS(50mg/kg) 30 minutes before modeling.The degree of myocardial injury was observed by hematoxylin-eosin(HE) staining.The expresionofcsteineaspartatespecicprotease-1Caspase1)asdetectedyimmunoistochemistryeexpresiosofCaspse1 andgasdermin D(GSDMD)proteincontentsinmyocardialtisseweredetectedbyWesternBlotResuts：Comparedwiththeshamgroup ......