D-半乳糖可诱导小鼠脑中β淀粉样蛋白\BACE1的表达增加(1)
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【中图分类号】R338; 【文献标识码】 A 【文章编号】1672-3873(2011)03-0363-02
【摘要】目的 探讨β淀粉样蛋白、BACE1在小鼠D-半乳糖中毒模型中的变化。方法 我们首先用D-半乳糖制做模拟Aβ代谢异常的阿尔茨海默病小鼠模型，并于用药后90天后取分脑。取脑前用五天的水迷宫实验在行为学上分析小鼠的记忆和学习能力。对所取分脑用Western杂交确定Aβ和BACE1蛋白的改变。结果：D-半乳糖处理的小鼠在水迷宫行为学测试中逃避潜伏期明显延长；Aβ和BACE1的蛋白水平明显升高。结论：D-半乳糖可诱导的小鼠脑中β淀粉样蛋白、BACE1的表达增加。
【关键词】D-半乳糖；β淀粉样蛋白；β分泌酶
The expression of β-Amyloid and BACE1 were upregulated in the mouse brain treated by D-galactose
Sun Na, Liu Shiliang, Qi Shengxia
(Jiao nan Wangtai Township Health Centers, Shan Dong, Qing Dao 266425)
Objective: The aim of this study was to investigate the expression of Aβ and BACE1 in the brain of mouse treated by D-galactose. Methods:Twenty four Kunming strain mice were separated into two equal groups randomly. One group was administered D-galactose for 90d, the control group with equivalent 0 ......
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