【摘 要】目的：探讨县级医院运用环孢素A治疗糖皮质激素抵抗性重度溃疡性结肠炎临床效果。方法：回顾分析笔者所在医院收治的61例糖皮质激素抵抗性重度溃疡性结肠炎患者的临床资料，观察组给予环孢素A治疗，对照组给予常规药物治疗。结果：观察组患者的治疗总有效率显著高于对照组，不良反应发生率显著低于对照组，组间差异显著(P<0.05)。结论：采用环孢素A治疗糖皮质激素抵抗重度溃疡性结肠炎的疗效较好，临床安全性较高。

    【关键词】环孢素 A；激素抵抗；溃疡性结肠炎

    Abstract Objective： To investigate the use of cyclosporine A in the treatment of glucocorticoid resistance in severe ulcerative colitis clinical effect of county hospital. Methods： The clinical data of 61 patients with glucocorticoid resistance in our hospital were analyzed the clinical data of severe ulcerative colitis patients ......