醒脑静对心脏骤停大鼠脑复苏后血清S-100β水平的影响
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[摘要]目的：观察醒脑静对心脏骤停大鼠脑复苏后S-100β蛋白水平的影响。方法：成年雄性SD大鼠54只，随机分为4组：正常对照组(NC，n=6)、假手术组(JSS，n=6)、常规复苏组(NE，n=6)、醒脑静复苏组(XNJ，n=6)，以窒息法复制心脏骤停大鼠模型。假手术组仅进行麻醉和气管插管、血管穿刺，不进行窒息及心肺复苏；常规复苏组：进行常规复苏；醒脑静组在常规复苏后加醒脑静15ml/kg。以ELISA法检测1h、24h血清S-100β水平结果：与正常对照组相比，常规治疗组大鼠血清S-100β水平均明显增高(P<0.05)，与常规治疗组相比，醒脑静治疗组血清SS-100β水平均明显降低(P<0.05).结论：醒脑静能够明显降低脑复苏后S-100β蛋白水平，从而达到对大鼠脑的保护作用。
[关键词]醒脑静；脑复苏；S-100B蛋白.
[Abstract Objective]To discuss a blood serum S-100 bet protein levels change after Xingnaojin resuscitation.Method: 40 Sprague-Dawley male rats were randomly divided into our groups(6 for each group)as normal group(NC)，shame-operated group(JSS)，CPR control group(NC)and XNJ-treated group(XNJ).Sudden cardiac arrest was induced on rat by asphyxia.At the onset of CPR 15ml/kg XNJ Was injected intravenously in the rats of group XNJ and 0.2ml/kg normal saline Was injected intravenously in the rats of group SN. At 1h、24h after ROSC，the venous blood was got to detcect the concentration of S-100β in each group ......
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