病毒性脑炎病儿脑脊液可溶性肿瘤坏死因子受体1与肿瘤坏死因子α的比值变化及其临床意义
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【摘要】：目的：探讨儿童急性病毒性脑炎(VE)脑脊液中可溶性肿瘤坏死因子受体1(sTNFR1)与肿瘤坏死因子α(TNF-α)的比值变化及其临床意义。方法:采用双抗体夹心ELISA法测定50例急性VE患儿(重症20例,轻症30例)脑脊液中TNF-α、sTNFR1的水平。结果:VE组患儿脑脊液中sTNFR1/TNF-α比值低于对照组，且重症组低于轻症组，差异有明显统计学意义(P<0.01) 。结论:VE急性期脑脊液sTNFR1/TNF-α比值变化与其病情密切相关，对病情判断有一定参考价值。
关键词：病毒性脑炎；肿瘤坏死因子-α； 肿瘤坏死因子可溶性受体1Clinical significance and change of sTNFR1 /TNFα in cerebrospinal fluid of children with virus encephalitis
Chen HongyanZhou JiayunZhang Aili
Abstract:Objective:To study the change and clinical significance of sTNFR1/TNFα in children with acute virus encephalitis(VE). Methods:The level of TNF- α and sTNFR1 in cerebrospinal fluid were determined by ELISA in 50 children who were admitted withVE,including 20 cases with severe VE (SVE) another 30 cases with mild VE(MVE) ......
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