小剂量HA配合G-CSF长程诱导缓解急性髓性白血病的临床观察
【中图分类号】R733.71 【文献标识码】B【文章编号】1672-5085(2008)03-0017-02【摘要】目的：探讨小剂量HA配合G-CSF治疗急性髓性白血病(AML)的近期疗效。方法：HHT 1mg，Ara-C 50mg静脉缓慢滴注21天～30天，当WBC≤1.5×109/L时酌情使用G-CSF(洁欣75μg～150μg 每日或隔日一次，待WBC≥4.0×109/L时停用)。结果：12例患者经小剂量HA配合G-CSF应用，获得完全缓解 8 例，部分缓解 2 例，未缓解 2 例；完全缓解率66.7%，总有效率83.3%。结论：小剂量HA配合G-CSF治疗AML疗效显著，值得临床推广。
【关键词】急性髓性白血病；高三尖杉酯碱；阿糖胞苷；髓性集落刺激因子
HA with small dose of G-CSF-induced long-term remission of acute myeloid leukemia clinical observation Liu Jianjun Xie Pinfang Zhang Zhisheng
【Abstract】Objective: Searchesdosage HA to coordinate G-CSF treats the acute marrow leukemia (AML) the short-term curative effect. Method: HHT 1mg, Ara-C the 50mg vein slow drop pours 21 day~30 days, when WBC≤1.5×109/L uses judgement to use G-CSF (clean joyful 75 mu g~150 mu g every day or every other day, treats WBC ≥4.0×109/L when stops using). Finally: 12 examples patients coordinate the G-CSF application after small dosage HA, obtains completely alleviates 8 examples, the part alleviates 2 examples, has not alleviated 2 examples; Completely alleviating rate 66.7%, total effectiveness 83.3%. Conclusion: Small dosage HA coordinates G-CSF to treat the AML curative effect to be remarkable, is worth the clinical promotion. ......
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