宫颈癌筛查现状与展望(2)
4.4联合筛查：细胞学检查和HPV基因检测是目前宫颈癌筛查的主要方法，两者结合应用可以同时了解患病变的程度以及明确HPV感染的型别，能够进一步提高确诊率和预判病情。付玉梅等采用HC II和TCT对377例宫颈病变的患者进行筛查，同时以病理组织学活检作为参考，结果表明两者联用时，对于CIN I及以上病变的敏感性、特异性、准确性、阳性预测值和阴性预测值均较单独使用一种技术时有显著提高。因此在发达地区可以联合使用的方法，例如RQ-PCR、基因芯片等高新技术，在经济落后的地区则难以实施，因此必须针对各地区的实际情况使用相宜的检测技术才能使筛查工作顺利开展。
5总结
目前，细胞学和组织活检等筛查技术已成熟稳定，而HPV基因检测技术则发展迅速。随着越来越多分子生物学领域的技术引人到HPV筛查工作中，诊断结果的灵敏度、特异性、重复性均不断得到提高。由于新兴方法都必须通过传统公认的方法进行验证，因此，在今后的发展中，将离不开新兴技术和传统技术的联合应用，扬长补短，为更有效地预防宫颈癌奠下基础。
参考文献
[1]Velema JP,Ferrer A,Figueroa M,et al.Burneng wood in the kitchen increases the risk of cervical neoplasia ni HPV infected women in Honduras[J].IntJCancer,2002,97(4)536-541.
[2]Smith JS,Green J,Berrington GA,et al.Cervical cancer and use of hormonal contraptives:asystematic review[J].Lancet,2003,361:1159-1167.
[3]Duensing S, Munger K. Centro some abnormalities and genomic instability induced by human papilloma virus on proteins[J]. Prog Cell Cycle Res,2003,5:383-391.
[4]Bosch F X, Lorincz A, Munoz N, et al. The causal relation between human Papilloma virusand cervical cancer[J]. J Clin Pathol,2002,55(4):244-265.
[5]Moreno V,Bosch FX,Munoz N,et al.Effect of oral contraceptives on risk of cervical cancer in women with human papilloma virus infection:the IARC multicentric case control study[J].Lancet,2002,359:1085.
[6]Boyle P,Vecchia C,Walker A,et al.FIGO annual report on the results of treatmenting gynecological Cancer[J].Journal of epidemiology and biostatictcs,2001,12:743.
[7]Laara E. Trends in mortality from cervical cancer in the Nordic countries: association with organized screening programmes. Lancet, 2005, 34(4): 247～249., http://www.100md.com(郑瑟韵)
5总结
目前，细胞学和组织活检等筛查技术已成熟稳定，而HPV基因检测技术则发展迅速。随着越来越多分子生物学领域的技术引人到HPV筛查工作中，诊断结果的灵敏度、特异性、重复性均不断得到提高。由于新兴方法都必须通过传统公认的方法进行验证，因此，在今后的发展中，将离不开新兴技术和传统技术的联合应用，扬长补短，为更有效地预防宫颈癌奠下基础。
参考文献
[1]Velema JP,Ferrer A,Figueroa M,et al.Burneng wood in the kitchen increases the risk of cervical neoplasia ni HPV infected women in Honduras[J].IntJCancer,2002,97(4)536-541.
[2]Smith JS,Green J,Berrington GA,et al.Cervical cancer and use of hormonal contraptives:asystematic review[J].Lancet,2003,361:1159-1167.
[3]Duensing S, Munger K. Centro some abnormalities and genomic instability induced by human papilloma virus on proteins[J]. Prog Cell Cycle Res,2003,5:383-391.
[4]Bosch F X, Lorincz A, Munoz N, et al. The causal relation between human Papilloma virusand cervical cancer[J]. J Clin Pathol,2002,55(4):244-265.
[5]Moreno V,Bosch FX,Munoz N,et al.Effect of oral contraceptives on risk of cervical cancer in women with human papilloma virus infection:the IARC multicentric case control study[J].Lancet,2002,359:1085.
[6]Boyle P,Vecchia C,Walker A,et al.FIGO annual report on the results of treatmenting gynecological Cancer[J].Journal of epidemiology and biostatictcs,2001,12:743.
[7]Laara E. Trends in mortality from cervical cancer in the Nordic countries: association with organized screening programmes. Lancet, 2005, 34(4): 247～249., http://www.100md.com(郑瑟韵)
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